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02 May 2021: Clinical Research

Parameters Indicating Development of Influenza-Associated Acute Necrotizing Encephalopathy: Experiences from a Single Center

Suyun Li 1AE* , Dandan Hu 2AE* , Peiqing Li 1AE* , Weiqiang Xiao 3AE* , Huixian Li 4ACE* , Guangming Liu 1C , Yongling Song 1C , Shuyao Ning 2C , Qiuyan Peng 1F , Danyang Zhao 5F , Minxiong Situ 5F , Wanqi Li 1B , Peiqun Wu 1B , Jipeng Zheng 1B , Yueting Liu 1B , Lin Hu 1B , Pengfei Wang 1B , Zhengbin Hu 1B , Wencheng Ma 1D , Jun Shen 1D , Sida Yang 2A*

DOI: 10.12659/MSM.930688

Med Sci Monit 2021; 27:e930688

Table 1 Demographic and clinical characteristics.

Characteristics, n (%) or as shownFA, n=4FS, n=8IAE, n=14IANE, n=5
Gender, Male3 (75)3 (37.5)10 (71.4)2 (40)
Age, years, mean (SD)5.2 (3.6)4.1 (2.4)5.4 (3.3)3.6 (1.9)
Weight, kg, median (IQR)15.35 (11.75, 21.85)15.5 (12, 18.35)18.5 (13.5, 26)15 (13, 17)
Onset date
 January4 (100)5 (62.5)7 (50)3 (60)
 December0 (0)1 (12.5)4 (28.57)1 (20)
 Others* 0 (0)2 (25)3 (21.43)1 (20)
Fever, day, median (IQR)4.5 (4, 9.5)2 (1, 2)1 (1, 3)* 3 (1, 4)
Temperature, °C, median (IQR)39 (39, 39.5)39.5 (39, 40)39 (39, 39.25)39 (39, 39)
Seizure
 No4 (100)0 (0)* 3 (21.4)0 (0),*
 1–20 (0)8 (100)4 (28.6)1 (20)
 ≥30 (0)0 (0)7 (50)4 (80)
Cough, yes4 (100)7 (87.5)9 (64.3)3 (60)
Vomiting, yes1 (25)0 (0)6 (42.9)2 (40)
Sleepiness, yes2 (50)2 (25)4 (28.6)1 (20)
Somnolence, yes1 (25)1 (12.5)1 (7.1)1 (20)
ADOC, yes0 (0)0 (0)0 (0)3 (60)
Alalia, yes0 (0)0 (0)3 (21.4)1 (20)
Gibberish, yes0 (0)0 (0)3 (21.4)0 (0)
Babinski’s sign, yes0 (0)0 (0)0 (0)3 (60)
Tachycardia, yes3 (75)0 (0)1 (7.1)1 (20)
Etiology
 Influenza A4 (100)8 (100)11 (73.3)4 (80)
 Influenza B0 (0)0 (0)4 (26.7)1 (20)
Treatment
 Oseltamivir/peramivir4 (100)7 (87.5)12 (85.7)5 (100)
 IVIG2 (50)0 (0)5 (35.7)5 (100)
 Glucocorticoids2 (50)0 (0)3 (21.4)4 (80)
 Antibiotics1 (25)2 (25)2 (14.3)3 (60)
 Tracheal intubation ventilator ventilation0 (0)0 (0)0 (0)2 (40)
Outcome
 Non-survivor/sequela0 (0)0 (0)0 (0)4 (80),**
* FA group were selected as controls and -value
** FS group were selected as controls and -value
*** IAE group were selected as controls and -value

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750