15 October 2021: Clinical Research
The Serum Metabolomics Study of Liver Failure and Artificial Liver Therapy Intervention
Shipeng Huang 1ABC , Dali Hu 2BCD , Songsong Yuan 2BCD , Ying He 2BCD , Chengmu Li 2BCD , Ying Zhu 2BCD , Xiaoping Wu 2AEF*DOI: 10.12659/MSM.930638
Med Sci Monit 2021; 27:e930638
Table 4 Qualitative and quantitative analysis of 35 common chromatographic peaks in serum before and after treatment in the artificial liver group.
| Number | Retention time | Endogenousmetabolites | Before artificial liver (Peak area ratio) | After artificial liver (Peak area ratio) |
|---|---|---|---|---|
| 1 | 6.516 | Boric acid | 0.0783±0.0329 | 0.0665±0.0269 |
| 2 | 8.546 | N,N-diethyl acetamide | 0.0300±0.0388 | 0.0264±0.0098 |
| 3 | 8.634 | 2-(methoxyimino)-propanoic acid | 0.1739±0.2287 | 0.0626±0.0142 |
| 4 | 8.957 | Lactic acid | 3.2434±2.5467 | 1.2633±0.5970 |
| 5 | 10.587 | L-alanine | 0.2015±0.2395 | 0.0856±0.0503 |
| 6 | 11.269 | Glycine | 0.2294±0.2651 | 0.1231±0.0445 |
| 7 | 11.640 | 2-hydroxybutyric ac | 0.1001±0.0812 | 0.0465±0.0187 |
| 8 | 12.934 | (R)-3-hydroxybutyri | 0.0818±0.0664 | 0.0380±0.0373 |
| 9 | 15.086 | L-valine | 0.1102±0.0673 | 0.0839±0.0229 |
| 10 | 15.980 | Urea | 1.4558±1.3914 | 0.7328±0.5738 |
| 11 | 17.210 | L-leucine | 0.0308±0.0347 | 0.0207±0.0159 |
| 12 | 17.457 | Phosphate | 0.3182±0.1096 | 0.1747±0.1114 |
| 13 | 17.527 | Glycerol | 0.2508±0.0659 | 0.2210±0.1004 |
| 14 | 17.904 | L-proline | 0.1979±0.1712 | 0.0915±0.0462 |
| 15 | 18.310 | Glycine | 0.0060±0.0107 | 0.0025±0.0051 |
| 16 | 20.374 | Serine | 0.0373±0.0220 | 0.0184±0.0106 |
| 17 | 21.027 | L-threonine | 0.0808±0.0566 | 0.0406±0.0273 |
| 18 | 21.204 | L-methionine | 0.0554±0.0389 | 0.0218±0.0138 |
| 19 | 22.586 | Aminomalonic acid | 0.0834±0.1614 | 0.0545±0.0135 |
| 20 | 23.286 | L-5-oxoproline | 0.4122±0.3854 | 0.3309±0.3060 |
| 21 | 23.562 | DL-phenylalanine | 0.0952±0.0347 | 0.0735±0.0366 |
| 22 | 23.798 | Creatinine | 0.0393±0.0369 | 0.0211±0.0154 |
| 23 | 24.056 | 2,3,4-trihydroxybut | 0.0271±0.0217 | 0.0163±0.0150 |
| 24 | 25.927 | D-(+)-arabitol | 0.0282±0.0104 | 0.0345±0.0102 |
| 25 | 27.150 | 1,5-anhydrohexitol | 0.1929±0.0790 | 0.1460±0.0645 |
| 26 | 27.756 | d-mannose | 7.0584±3.5964 | 6.3458±2.4587 |
| 27 | 27.956 | D-(+)-talose | 1.9446±1.9885 | 1.4184±0.8479 |
| 28 | 29.056 | Palmitic acid | 0.6717±0.1822 | 0.6383±0.2589 |
| 29 | 30.103 | Myo-inositol | 0.0813±0.0718 | 0.0545±0.0640 |
| 30 | 31.368 | (Z,Z)-9,12-octadeca | 0.1491±0.1014 | 0.1126±0.0976 |
| 31 | 31.438 | (E)-13-octadecenoic | 0.2961±0.1904 | 0.2427±0.2180 |
| 32 | 31.844 | Stearic acid | 0.3015±0.0854 | 0.3063±0.1596 |
| 33 | 38.220 | 1-Monopalmitin | 0.2699±0.0647 | 0.2670±0.0606 |
| 34 | 41.255 | Glycerol monosteara | 0.3375±0.1561 | 0.2114±0.0547 |
| 35 | 46.431 | Cholesterol | 1.7804±0.4867 | 0.7480±0.4744 |