The Serum Metabolomics Study of Liver Failure and Artificial Liver Therapy Intervention

Shipeng Huang; Dali Hu; Songsong Yuan; Ying He; Chengmu Li; Ying Zhu; Xiaoping Wu

doi:10.12659/MSM.930638

15 October 2021: Clinical Research

The Serum Metabolomics Study of Liver Failure and Artificial Liver Therapy Intervention

Shipeng Huang ^1ABC , Dali Hu ^2BCD , Songsong Yuan ^2BCD , Ying He ^2BCD , Chengmu Li ^2BCD , Ying Zhu ^2BCD , Xiaoping Wu ^2AEF*

DOI: 10.12659/MSM.930638

Med Sci Monit 2021; 27:e930638

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Table 3 Qualitative and quantitative analysis of 35 chromatographic peaks in serum from the liver failure group and chronic hepatitis groups and from the healthy control group.

Number	Retention time	Endogenousmetabolites	Healthy control group (Peak area ratio)	Liver failure group (Peak area ratio)	Chronic hepatitis group (Peak area ratio)	Liver failure artificial liver group (Peak area ratio)
1	6.516	Boric acid	0.0557±0.0206	0.0285±0.0163	0.0593±0.0209	0.0541±0.0054
2	8.546	N,N-diethyl acetamide	0.0244±0.0123	0.0339±0.0453	0.0166±0.0081	0.0207±0.0123
3	8.634	2-(methoxyimino)-propanoic acid	0.0941±0.2183	0.0846±0.2250	0.1955±0.1567	0.1248±0.0241
4	8.957	Lactic acid	1.6453±0.6144	3.3355±2.7454	1.8004±0.9988	1.7151±0.1205
5	10.587	L-alanine	0.0853±0.0204	0.1168±0.1166	0.0856±0.0350	0.0927±0.0354
6	11.269	Glycine	0.1211±0.1289	0.0760±0.0602	0.2922±0.1592	0.2289±0.0843
7	11.640	2-hydroxybutyric acid	0.0588±0.0204	0.1011±0.0831	0.0628±0.0196	0.0607±0.0401
8	12.934	(R)-3-hydroxybutyric acid	0.1029±0.0795	0.1339±0.1301	0.0873±0.0456	0.0948±0.0379
9	15.086	L-valine	0.1018±0.0297	0.0938±0.0520	0.1213±0.0521	0.1124±0.0218
10	15.980	Urea	1.7944±1.1465	1.6663±1.2914	1.2255±0.4506	1.4851±0.0985
11	17.210	L-leucine	0.0176±0.0083	0.0267±0.0269	0.0314±0.0248	0.0283±0.0377
12	17.457	Phosphate	0.4465±0.1169	0.4517±0.2117	0.3889±0.1438	0.4238±0.0864
13	17.527	Glycerol	0.2428±0.0929	0.3195±0.1193	0.1805±0.0435	0.2249±0.0347
14	17.904	L-Proline	0.0880±0.0189	0.1630±0.1296	0.0985±0.0402	0.0919±0.0134
15	18.310	Glycine	0.0039±0.0103	0.0062±0.0219	0.0097±0.0071	0.0084±0.0146
16	20.374	Serine	0.0148±0.0090	0.0282±0.0240	0.0227±0.0165	0.0216±0.0513
17	21.027	L-threonine	0.0231±0.0106	0.0600±0.0640	0.0330±0.0177	0.0289±0.0094
18	21.204	L-methionine	0.0069±0.0063	0.0586±0.0656	0.0062±0.0064	0.0068±0.0106
19	22.586	Aminomalonic acid	0.0678±0.1347	0.0347±0.0172	0.1173±0.0896	0.0894±0.0664
20	23.286	L-5-oxoproline	0.2219±0.0641	0.4132±0.5095	0.1829±0.0558	0.2067±0.0431
21	23.562	DL-phenylalanine	0.0547±0.0156	0.1044±0.0459	0.0546±0.0143	0.0553±0.0582
22	23.798	Creatinine	0.0334±0.0181	0.0383±0.0373	0.0259±0.0102	0.0298±0.1006
23	24.056	2,3,4-trihydroxybutyric acid	0.0166±0.0090	0.0338±0.0324	0.0152±0.0098	0.0115±0.0194
24	25.927	D-(+)-arabitol	0.0353±0.0246	0.0253±0.0131	0.0258±0.0119	0.0305±0.0409
25	27.150	1,5-anhydrohexitol	0.2217±0.1018	0.2539±0.1820	0.2762±0.0997	0.2821±0.0348
26	27.756	d-mannose	7.4102±1.1994	7.0861±3.0331	5.4392±1.3233	6.4089±0.8594
27	27.956	D-(+)-talose	1.5854±0.4940	1.9203±1.5121	0.9606±0.3202	1.4429±0.1340
28	29.056	Palmitic acid	0.5809±0.1340	0.8496±0.2942	0.5304±0.1348	0.5675±0.0645
29	30.103	Myo-inositol	0.0614±0.0409	0.0816±0.0636	0.0328±0.0123	0.0459±0.0458
30	31.368	(Z,Z)-9,12-octadecadienoic acid	0.1156±0.0709	0.2173±0.1345	0.1092±0.0449	0.9856±0.0345
31	31.438	(E)-13-octadecenoic acid	0.2177±0.1320	0.4594±0.2823	0.2013±0.0934	0.2264±0.0387
32	31.844	Stearic acid	0.2371±0.0551	0.3420±0.1183	0.2459±0.0678	0.2508±0.1005
33	38.220	1-Monopalmitin	0.2405±0.0596	0.2112±0.0790	0.1954±0.0313	0.2186±0.0954
34	41.255	Glycerol monostearate	0.3886±0.1095	0.3802±0.1050	0.1362±0.0239	0.2633±0.0097
35	46.431	Cholesterol	1.1187±0.3268	2.0769±0.7983	0.7551±0.1954	0.9842±0.0895

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The Serum Metabolomics Study of Liver Failure and Artificial Liver Therapy Intervention

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