Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students

Jing Zhang; Mengyi Yang; Pengfei Luan; Wei Jia; Qiujun Liu; Zhanbing Ma; Jie Dang; Hong Lu; Qian Ma; Yanfeng Wang; Chunlan Mu; Zhenghao Huo

doi:10.12659/MSM.930591

16 March 2021: Clinical Research

Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students

Jing Zhang ^12ABCDEF , Mengyi Yang ^1B , Pengfei Luan ^1B , Wei Jia ^1B , Qiujun Liu ^1B , Zhanbing Ma ^1A , Jie Dang ^1A , Hong Lu ^1A , Qian Ma ^1B , Yanfeng Wang ^1B , Chunlan Mu ^1B , Zhenghao Huo ^13AG*

DOI: 10.12659/MSM.930591

Med Sci Monit 2021; 27:e930591

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Table 4 The relationship between CYP SNPs and L2D: 4D, R2D: 4D, and DR-L in men and women.

Genotype	L2D: 4D			R2D: 4D			DR-L
Genotype	BETA	STAT	P-adjusted	BETA	STAT	P-adjusted	BETA	STAT	P-adjusted

Total	0.0025	1.361	0.298	−0.0004	−0.195	0.845	−0.0029	−1.869	0.372
Male	0.0049	1.773	0.288	0.0008	0.319	0.818	−0.0040	−1.856	0.291
Female	0.0005	0.215	0.954	−0.0013	−0.503	0.820	−0.0018	−0.844	0.946

Total	−0.0004	−0.237	0.887	−0.0012	−0.723	0.627	−0.0008	−0.589	0.613
Male	−0.0020	−0.808	0.566	−0.0025	−1.073	0.426	−0.0005	−0.279	0.851
Female	0.0011	0.472	0.954	−1.6×10	−0.006	0.995	−0.0011	−0.537	0.946

Total	0.0024	0.822	0.617	0.0009	0.302	0.832	−0.0015	−0.620	0.613
Male	0.0046	1.119	0.566	0.0073	1.871	0.200	0.0027	0.849	0.595
Female	0.0004	0.094	0.954	−0.0062	−1.439	0.603	−0.0066	−1.829	0.618

Total	−0.0035	−2.038	0.176	−0.0050	−2.863	0.032^*	−0.0014	−1.005	0.613
Male	−0.0055	−2.082	0.228	−0.0086	−3.426	0.008^**	−0.0031	−1.482	0.291
Female	−0.0023	−1.045	0.889	−0.0023	−0.9664	0.790	3.69×10	0.019	0.985

Total	0.0036	1.808	0.176	0.0032	1.59	0.337	−0.0004	−0.246	0.805
Male	0.0091	3.087	0.026	0.0087	3.075	0.013	−0.0004	−0.174	0.862
Female	−0.0017	−0.645	0.954	−0.0021	−0.7386	0.790	−0.0004	−0.159	0.985

Total	0.0034	1.921	0.176	0.0024	1.319	0.375	−0.0011	−0.708	0.613
Male	0.0025	0.934	0.566	0.0019	0.7177	0.568	−0.0007	−0.313	0.851
Female	0.0045	1.916	0.336	0.0030	1.215	0.675	−0.0015	−0.694	0.946

Total	6.1x10-5	0.030	0.976	0.0027	1.344	0.375	0.0027	1.588	0.400
Male	−0.0003	−0.109	0.913	0.0034	1.166	0.419	0.0038	1.554	0.291
Female	−0.0001	−0.057	0.954	0.0017	0.599	0.820	0.0019	0.782	0.946

Total	−0.0006	−0.300	0.887	0.0020	0.944	0.518	0.0025	1.502	0.400
Male	−0.0007	−0.223	0.899	0.0028	0.968	0.445	0.0035	1.459	0.291
Female	−0.0011	−0.407	0.954	0.0007	0.243	0.881	0.0018	0.750	0.946
value was adjusted by Benjamini-Hochberg method; ^* ^** SNPs – single-nucleotide polymorphisms; L2D: 4D – left hand second-to-fourth digit ratio; R2D: 4D – right hand second-to-fourth digit ratio; D – R2D: 4D minus L2D: 4D.

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Associations Between Cytochrome P450 (CYP) Gene Single-Nucleotide Polymorphisms and Second-to-Fourth Digit Ratio in Chinese University Students

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