22 July 2021: Database Analysis
Identification of Key Genes and Underlying Mechanisms in Acute Kawasaki Disease Based on Bioinformatics Analysis
Side Gao BCDEF , Wenjian Ma BCD , Xuze Lin BCD , Sizhuang Huang BC , Mengyue Yu AG*DOI: 10.12659/MSM.930547
Med Sci Monit 2021; 27:e930547
Supplementary Table 2 The top 10 results of GO-BP enrichment analyses of the shared DEGs.
| GO-BP term | Count | Gene | P value |
|---|---|---|---|
| GO: 0006955~immune response | 23 | IFITM3, CCR1, CD96, IL1RN, CEBPB, SLC11A1, NCF4, OSM, LILRB2, CST7, LTB4R, FCAR, GZMH, TGFBR3, AIM2, CD8A, GPR183, BPI, LTBR, PGLYRP1, IL7R, FCGR1B, IL18R1 | 1.85E-09 |
| GO: 0007166~cell surface receptor signaling pathway | 17 | CCR1, CDA, SIGLEC9, KLRB1, LY96, CD3G, LILRB2, LILRB3, MAPK14, CD2, ADGRG3, ADGRG1, CD8A, IL7R, CLEC2D, MYD88, KLRG1 | 7.43E-08 |
| GO: 0045087~innate immune response | 20 | ZNF683, CR1, LY96, NLRC4, LILRA5, TREML1, FGR, CLEC4D, AIM2, FES, LCN2, S100A12, PADI4, PGLYRP1, TLR5, CD55, MYD88, CAMP, KLRG1, MSRB1 | 3.47E-07 |
| GO: 0006954~inflammatory response | 18 | CCR1, CEBPB, TNFAIP6, EPHX2, SLC11A1, FPR1, LY96, NLRC4, LTB4R, AIM2, NFKBIZ, C3AR1, PROK2, S100A12, LTBR, TLR5, MYD88, KLRG1 | 1.20E-06 |
| GO: 0007155~cell adhesion | 17 | CCR1, CD96, CSF3R, SIGLEC9, TNFAIP6, ITGA2B, SIGLEC10, CD2, ADGRG1, CEACAM1, ITGAX, CYP1B1, FLOT2, SIRPA, GAS6, NECTIN2, SIGLEC5 | 5.71E-05 |
| GO: 0006935~chemotaxis | 9 | CCR1, FES, FPR1, C3AR1, PROK2, CMTM2, PLP2, RNASE2, MAPK14 | 6.65E-05 |
| GO: 0050776~regulation of immune response | 10 | TREML1, CD96, SIGLEC9, KLRB1, CD8A, CD3G, LILRB2, CLEC2D, NECTIN2, OSCAR | 1.74E-04 |
| GO: 0002250~adaptive immune response | 9 | ZNF683, CLEC4D, GPR183, LILRB2, LILRB3, LILRA2, FCGR1B, LILRA3, SKAP1 | 2.54E-04 |
| GO: 0071222~cellular response to lipopolysaccharide | 8 | SBNO2, CEBPB, LCN2, TSPO, LILRB2, MAPK14, TLR5, CAMP | 2.71E-04 |
| GO: 0042742~defense response to bacterium | 8 | CEBPB, CLEC4D, ANXA3, SLC11A1, S100A12, NLRC4, TLR5, CAMP | 3.71E-04 |