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06 May 2021: Clinical Research

Establishment and Verification of a Prediction Model for Symptomatic Radiation Pneumonitis in Patients with Esophageal Cancer Receiving Radiotherapy

Liu-Ting Yang 1ABCDEFG , Lei Zhou 1BC , Long Chen 1ACDE , Shi-Xiong Liang 1ADE , Jiang-Qiong Huang 1DEF , Xiao-Dong Zhu 12ACDEF*

DOI: 10.12659/MSM.930515

Med Sci Monit 2021; 27:e930515

Table 3 Univariate analysis of clinicopathologic, dosimetric, and inflammatory parameters in predicting symptomatic radiation pneumonitis.

Sex (Male vs Female)0.0871.000
Age (≤60 vs >60; years)0.0650.799
Smoking (yes vs no)0.1200.729
Smoking index (0.0090.926
Drinking (yes vs no)0.0420.838
Location (Cervical/upper/middle/lower/multifocal)3.8430.428
T stage (T1–T2 vs T3–T4)2.3690.228
N stage (N0–N1 vs N2–N3)0.2440.621
M stage (M0 vs M1)1.7190.340
Clinical stages (I–II vs III–IV)0.3580.809
Chemotherapy (PF regimen vs TP regimen)2.7970.094
Chemotherapy cycle (1.5150.218
Pulmonary bulla (0/1/2/3)2.2810.516
Fractional dose (0.3570.770
MLD (5.3360.021
V5 (6.4710.011
V10 (7.2620.007
V15 (4.8110.028
V20 (4.8130.028
V25 (1.660.198
V30 (1.5940.207
V35 (1.4320.231
V40 (1.3780.240
NLR during RT (3.8240.051
PLR during RT (6.5040.004
LMR during RT (5.0170.025
SII during RT (4.4770.034
NLR at the end of RT (11.7280.001
PLR at the end of RT (6.3700.012
LMR at the end of RT (9.2660.002
SII at the end of RT (6.3460.012
PF – platinum-fluorouracil; TP – taxus-platinum; MLD – mean lung dose; NLR – neutrophil-to-lymphocyte ratio; RT – radiation therapy; PLR – platelet-to-lymphocyte ratio; LMR – lymphocyte-to-monocyte ratio; SII – systemic immune inflammation index.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750