Association Between TLR4 Gene Polymorphisms and Risk of Preeclampsia: Systematic Review and Meta-Analysis

02 August 2021: Meta-Analysis

Association Between Gene Polymorphisms and Risk of Preeclampsia: Systematic Review and Meta-Analysis

Manni Sun ^BE , Hui Jiang ^BF , Tao Meng ^AF , Peiyan Liu ^BC , Haiying Chen ^ACG*

DOI: 10.12659/MSM.930438

Med Sci Monit 2021; 27:e930438

Table 3 Main results for pooled ORs in the meta-analysis.

Genetic model	Test of association			Test of heterogeneity		Test of publication bias (Egger)		Type of model
Genetic model	OR	95% CI	P	I2 (%)	P	T	P	Type of model

G vs A	0.96	0.51–1.78	0.887	67.9	0.014	1.28	0.289	Random
GG vs AA	1.22	0.38–3.90	0.740	0.0	0.438	−1.53	0.225	Fixed
GG vs GA	1.18	0.32–4.34	0.802	0.0	0.814	−0.53	0.630	Fixed
GG+GA vs AA	0.94	0.53–1.67	0.826	59.8	0.041	1.40	0.256	Random
GG vs GA+AA	1.22	0.38–3.93	0.743	0.0	0.479	−1.40	0.255	Fixed

T vs C	1.07	0.48–2.38	0.871	71.5	0.015	0.87	0.474	Random
TT vs CC	1.08	0.03–4.63	0.922	17.8	0.296	−40.8	0.016	Fixed
TT vs TC	0.82	0.15–4.47	0.818	0.0	0.727	−2.17	0.275	Fixed
TT+TC vs CC	1.07	0.50–2.29	0.854	65.9	0.032	0.95	0.441	Random
TT vs TC+CC	1.05	0.24–4.57	0.953	8.7	0.334	−41.69	0.015	Fixed