13 July 2021: Clinical Research
Risk Factors for Fentanyl-Induced Cough Following General Anesthesia in Adults: A Retrospective Study from a Single Center in China
Xiao Zhao ABCDEF* , Hong Wang ABCDEF* , Hui-Juan Wang BCDEF , Yun Wang BCDEF , Yi-An Xing BCD , Shi-Tong Li ABC* , Lian-Hua Chen ABC*DOI: 10.12659/MSM.930369
Med Sci Monit 2021; 27:e930369
Table 3 The risk factors for the incidence of nausea by multivariate logistic regression analysis.
| Variables | β value | SD | Wald chi-square | OR (95% CI) | P value |
|---|---|---|---|---|---|
| Intercept | −6.473 | 2.871 | 5.082 | 0.024 | |
| Gender | −0.498 | 0.418 | 1.425 | 0.607 (0.268–1.377) | 0.233 |
| Age (years) | 0.000 | 0.014 | 0.001 | 1.000 (0.974–1.028) | 0.982 |
| Type of surgery | 0.517 | 0.500 | 1.066 | 1.676 (0.629–4.468) | 0.302 |
| Operative time (min) | 0.000 | 0.004 | 0.009 | 1.000 (0.993–1.008) | 0.926 |
| BMI | 0.136 | 0.073 | 3.539 | 1.146 (0.994–1.321) | 0.060 |
| Intraoperative blood loss (ml) | −0.001 | 0.001 | 0.359 | 0.999 (0.997–1.001) | 0.549 |
| Smoking status | −0.925 | 0.660 | 1.964 | 0.397 (0.109–1.446) | 0.161 |
| Alcohol intake | 0.040 | 0.659 | 0.004 | 1.041 (0.286–3.789) | 0.951 |
| Pharyngitis | −0.417 | 0.530 | 0.621 | 0.659 (0.233–1.860) | 0.431 |
| History of gastroesophageal reflux | 0.513 | 0.710 | 0.522 | 1.671 (0.415–6.720) | 0.470 |
| Other digestive tract diseases | 0.478 | 0.711 | 0.453 | 1.614 (0.401–6.496) | 0.501 |
| Hypertension | 0.145 | 0.478 | 0.092 | 1.155 (0.453–2.947) | 0.762 |
| Diabetes mellitus | −0.023 | 0.584 | 0.002 | 0.977 (0.311–3.073) | 0.969 |
| History of asthma | 0.226 | 0.814 | 0.077 | 1.254 (0.254–6.182) | 0.781 |
| Psychiatric history | −13.224 | 688.726 | 0.000 | 0.000 (0.000–I) | 0.985 |
| History of respiratory infection (within 2 months) | −12.747 | 706.969 | 0.000 | 0.000 (0.000–I) | 0.986 |
| History of surgery | −0.411 | 1.101 | 0.139 | 0.663 (0.077–5.736) | 0.709 |
| Lidocaine (2%ml) | −0.053 | 0.120 | 0.198 | 0.948 (0.749–1.199) | 0.656 |
| Palliative (Dexmedetomidinevs midazolam) | 0.003 | 0.405 | 0.000 | 1.003 (0.454–2.217) | 0.994 |
| Sufentanil (ug) | . | ||||
| 10 | – | – | – | Ref | . |
| 15 | −1.103 | 1.679 | 0.432 | 0.332 (0.012–8.907) | 0.511 |
| 20 | −3.045 | 2.074 | 2.156 | 0.048 (0.001–2.773) | 0.142 |
| Propofol (mg) | −0.024 | 0.027 | 0.789 | 0.976 (0.926–1.029) | 0.374 |
| Rocuronium bromide | 0.106 | 0.069 | 2.385 | 1.112 (0.972–1.272) | 0.123 |
| Sufentanil | 0.024 | 0.029 | 0.677 | 1.024 (0.968–1.084) | 0.411 |
| BMI – body mass index; CI – confidence interval; OR – odds ratio; SD – standard deviation. | |||||