23 August 2021: Clinical Research
Cost-Benefit Analysis of Using A Single Dose of Tranexamic Acid in Degenerative Lumbar Scoliosis Patients Undergoing Long-Segment Spinal Fusion Surgery: A Retrospective Study
Lei Yuan 123BCE* , Yu Jiang 123BD* , Yinhao Liu 123BF , Yan Zeng 123ADF* , Zhongqiang Chen 123A , Weishi Li 123BDOI: 10.12659/MSM.930352
Med Sci Monit 2021; 27:e930352
Table 5 Data from subanalyses of patients undergoing osteotomy surgery.
| NTXA (n= 60) | TXA (n=41) | P value | |
|---|---|---|---|
| Sex, F/M (n) | 54/6 | 39/2 | 0.575 |
| Age (year) | 63.12±6.73 | 62.76±5.11 | 0.761 |
| BMI (Kg/m) | 25.74±3.76 | 25.48±3.63 | 0.725 |
| Hypertension (n,%) | 29 (48.3%) | 17 (41.5%) | 0.496 |
| Diabetes mellitus (n,%) | 4 (6.7%) | 4 (9.8%) | 0.850 |
| EBV (mL) | 4429.83±624.12 | 4445.98±656.28 | 0.901 |
| ASA physical status, I: II: III (n) | 3:54:3 | 7:32:2 | 0.139 |
| Cobb angle (°) | 32.96±11.21 | 33.48±11.42 | 0.822 |
| CSVL (mm) | 19.87±13.33 | 21.68±13.99 | 0.512 |
| SVA (mm) | 59.06±42.11 | 56.83±34.95 | 0.780 |
| LL (°) | 19.32±20.74 | 20.06±21.34 | 0.863 |
| Pre-operative Hb (g/L) | 131.33±11.53 | 132.73±14.11 | 0.586 |
| Pre-operative hematocrit (%) | 40.07±4.5 | 40.15±4.0 | 0.927 |
| Pre-operative PLT (×10/L) | 222.65±59.13 | 227.90±53.57 | 0.650 |
| Pre-operative APTT (S) | 32.17±3.50 | 31.75±3.02 | 0.538 |
| Pre-operative INR | 0.98±0.06 | 0.99±0.06 | 0.894 |
| Post-operative D1 Hb (g/L) | 102.78±18.18 | 101.15±14.16 | 0.631 |
| Post-operative D1 hematocrit (%) | 30.76±5.5 | 30.34±4.1 | 0.678 |
| Hb change (g/L) | 28.42±18.83 | 31.59±12.75 | 0.319 |
| Hematocrit change (%) | 10±5.8 | 10±3.6 | 0.741 |
| ASD-S score | 25.05±4.90 | 24.90±5.44 | 0.887 |
| Duration of surgery (min) | 283.90±67.62 | 287.61±69.30 | 0.789 |
| Fixation and fused levels (n) | 6.58±1.49 | 6.34±1.44 | 0.419 |
| Decompression levels (n) | 2.83±1.30 | 3.15±1.20 | 0.224 |
| Osteotomy grades, 2: 3 (n,%) | 47:13 | 34:7 | 0.569 |
| No. of intervertebral fusion (n) | 1.20±1.15 | 1.40±0.97 | 0.388 |
| IBL (mL) | 1633.65±962.49 | 1040.88±560.37 | ** |
| Postoperative drainage (mL) | 1412.83±538.45 | 1205.68±367.76 | * |
| Total blood loss (mL) | 3046.48±1274.02 | 2246.56±815.01 | * |
| Cell saver (mL) | 544.55±320.83 | 346.96±186.79 | ** |
| Intraoperative PRBC | 3.62±2.32 | 2.34±1.96 | ** |
| Intraoperative transfusion rate (n,%) | 52 (86.7%) | 28 (68.3%) | * |
| Postoperative PRBC | 2.10±2.37 | 1.39±1.66 | 0.100 |
| Postoperative transfusion rate (n,%) | 35 (58.3%) | 20 (48.8%) | 0.344 |
| 12.25±6.39 | 10.83±3.82 | 0.205 | |
| 1 (1.7%) | 0 | >0.999 | |
| Values are presented as the mean±SD or number (%). TXA – the group that received tranexamic acid; NTXA – the historically recruited no-TXA group; BMI – body mass index; EBV – estimated blood volume; ASA – American Society of Anesthesiologists; CSVL – coronal vertical axis from the central sacrum vertical line; SVA – sagittal vertical axis; LL – lumbar lordosis; Hb – hemoglobin; PLT – platelets; APTT – activated partial thromboplastin time; INR – international normalized ratio; ASD-S – adult spinal deformity surgery; IBL – intraoperative blood loss; PRBC – packed red blood cells; DVT – deep vein thrombosis; PE – pulmonary embolism. * ** | |||