23 August 2021: Clinical Research
Cost-Benefit Analysis of Using A Single Dose of Tranexamic Acid in Degenerative Lumbar Scoliosis Patients Undergoing Long-Segment Spinal Fusion Surgery: A Retrospective Study
Lei Yuan 123BCE* , Yu Jiang 123BD* , Yinhao Liu 123BF , Yan Zeng 123ADF* , Zhongqiang Chen 123A , Weishi Li 123BDOI: 10.12659/MSM.930352
Med Sci Monit 2021; 27:e930352
Table 1 Data for patients with or without intraoperative TXA.
| NTXA (n=119) | TXA (n=54) | P value | |
|---|---|---|---|
| Sex, F/M (n) | 98/21 | 50/4 | 0.076 |
| Age (years) | 63.50±6.51 | 63.32±5.48 | 0.850 |
| BMI (Kg/m) | 25.81±4.02 | 25.61±3.60 | 0.758 |
| Hypertension (n,%) | 52 (43.70%) | 22 (40.74%) | 0.716 |
| Diabetes mellitus (n,%) | 15 (12.61%) | 8 (14.81%) | 0.692 |
| EBV (mL) | 4557.35±767.24 | 4498.98±643.28 | 0.627 |
| ASA physical status, I: II: III (n) | 13:100:6 | 9:42:3 | 0.572 |
| Cobb angle (°) | 29.08±10.49 | 31.30±10.88 | 0.239 |
| CSVL (mm) | 20.29±11.84 | 22.59±13.83 | 0.293 |
| SVA (mm) | 57.85±42.08 | 54.75±35.42 | 0.638 |
| LL (°) | 25.45±19.26 | 22.88±21.38 | 0.434 |
| Preoperative Hb (g/L) | 134.01±12.93 | 133.00±13.45 | 0.640 |
| Preoperative hematocrit (%) | 40.56±4.2 | 40.35±3.8 | 0.752 |
| Preoperative PLT (×10/L) | 223.26±61.08 | 232.30±53.54 | 0.352 |
| Preoperative APTT (S) | 32.25±3.04 | 31.76±2.92 | 0.320 |
| Preoperative INR | 0.99±0.06 | 0.98±0.06 | 0.641 |
| Postoperative D1 Hb (g/L) | 103.62±16.92 | 102.09±14.49 | 0.569 |
| Postoperative D1 hematocrit (%) | 30.97±4.99 | 30.72±4.24 | 0.758 |
| Hb change (g/L) | 31.58±15.60 | 31.28±12.46 | 0.740 |
| Hematocrit change (%) | 10.00±5.1 | 10±3.6 | 0.583 |
| ASD-S score | 22.92±4.88 | 23.80±5.34 | 0.287 |
| Duration of surgery (min) | 261.80±63.16 | 271.33±69.47 | 0.374 |
| Fixation and fused levels (n) | 5.77±1.51 | 5.96±1.48 | 0.421 |
| Decompression levels (n) | 3.05±1.21 | 3.13±1.12 | 0.684 |
| Osteotomy (n,%) | 60 (50.42%) | 41 (75.93%) | ** |
| Osteotomy grades, 0: 2: 3 (n,%) | 59:47:13 | 13:34:7 | ** |
| No. of intervertebral fusion (n) | 1.27±0.98 | 1.41±0.90 | 0.383 |
| IBL (mL) | 1381.54±854.75 | 963.43±548.63 | ** |
| Postoperative drainage (mL) | 1399.30±501.59 | 1164.65±380.09 | ** |
| Total blood loss (mL) | 2780.84±1119.68 | 2128.07±816.29 | ** |
| Cell saver (mL) | 460.51±284.92 | 321.14±182.86 | ** |
| Intraoperative PRBC | 2.80±2.29 | 2.19±1.88 | 0.087 |
| Intraoperative transfusion rate (n,%) | 88 (73.95%) | 36 (66.67%) | 0.325 |
| Postoperative PRBC | 2.11±2.47 | 1.32±1.62 | * |
| Postoperative transfusion rate (n,%) | 69 (57.98%) | 25 (46.30%) | 0.153 |
| 11.63±5.63 | 10.46±3.66 | 0.165 | |
| 1 (0.84%) | 0 (0%) | >0.999 | |
| Values are presented as the mean ± SD or number (%). TXA – the group that received tranexamic acid; NTXA – the historically recruited no-TXA group; BMI – body mass index; EBV – estimated blood volume; ASA – American Society of Anesthesiologists; CSVL – coronal vertical axis from the central sacrum vertical line; SVA – sagittal vertical axis; LL – lumbar lordosis; Hb – hemoglobin; PLT – platelets; APTT – activated partial thromboplastin time; INR – international normalized ratio; ASD-S – adult spinal deformity surgery; IBL – intraoperative blood loss; PRBC – packed red blood cells; DVT – deep vein thrombosis; PE – pulmonary embolism. * ** | |||