Protective Effects of Bone Marrow Mesenchymal Stem Cells (BMMSCS) Combined with Normothermic Machine Perfusion on Liver Grafts Donated After Circulatory Death via Reducing the Ferroptosis of Hepatocytes

11 June 2021: Animal Study

Dong Sun ^1BCDEF* , Liu Yang ^1BCEF* , Weiping Zheng ^23CE , Huan Cao ^14BD , Longlong Wu ^5DF , Hongli Song ^26AG*

DOI: 10.12659/MSM.930258

Med Sci Monit 2021; 27:e930258

Table 1 DCD donor livers ameliorated by NMP combined with BMMSCs.

Parameters	Normal group	SCS group	P group		BP group
Parameters	Normal group	SCS group	Value	P value (vs SCS group)	Value	P value (vs SCS group)	P value (vs P group)
ALT (U/l)	31.74±2.00	n.a.	97.40±2.91	n.a.	72.84±2.00	n.a.	0.003^#
AST (U/l)	49.24±2.77	n.a.	124.62±3.94	n.a	97.30±4.26	n.a.	0.001^#
Lactic acid (mmol/l)	2.04±0.05	n.a.	2.48±0.04	n.a.	2.34±0.11	n.a.	0.107
Cumulative bile (ml)	n.a.	n.a.	2.92±0.04	n.a.	3.27±0.06	n.a.	0.001^#
Suzuki score	0.40±0.55	7.60±0.55	3.40±0.55	^*	1.60±0.55	^*	0.016^#
Mean±SD. ^* ^# n.a. – applicable.