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09 July 2021: Clinical Research

Secondary Immunodeficiency and Hypogammaglobulinemia with IgG Levels of <5 g/L in Patients with Multiple Myeloma: A Retrospective Study Between 2012 and 2020 at a University Hospital in China

Chunmei Ye 12BCEF* , Weiwei Chen 3EF* , Qi Gao 12B , Yanxia Chen 4B , Xiaolu Song 5B , Sujie Zheng 2C* , Jinlin Liu 2AEG*

DOI: 10.12659/MSM.930241

Med Sci Monit 2021; 27:e930241

Table 5 Univariate analysis of secondary immunodeficiency in patients with multiple myeloma (MM) and matched MM patients.

VariableHazard ratio95% Confidence intervalP value
Hypogammaglobulinemia (IgG0.3690.220–0.618
Sex (Male vs Female)0.5290.298–0.9360.029
Age (≤65 years vs >65 years)1.3930.817–2.3730.223
Calcium (normal vs abnormal) (141 cases available)1.2200.788–1.8900.372
Hemoglobin (≤90 g/L vs >90 g/L) (145 cases available)0.6790.433–1.0670.093
Creatinine (≤110 μmol/L vs>110 μmol/L)1.4470.873–2.3990.152
Albumin (≤3.5 g/dL vs >3.5 g/dL) (146 cases available)0.5380.294–0.9840.044
β-Microglobulin (≤3.5 mg/L vs >3.5 mg/L) (103 cases available)0.8340.628–1.1080.210
Lactate dehydrogenase (≤250 U/L vs >250 U/L) (141 cases available)1.0460.418–2.6190.923

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750