Secondary Immunodeficiency and Hypogammaglobulinemia with IgG Levels of <5 g/L in Patients with Multiple Myeloma: A Retrospective Study Between 2012 and 2020 at a University Hospital in China

09 July 2021: Clinical Research

Chunmei Ye ^12BCEF* , Weiwei Chen ^3EF* , Qi Gao ^12B , Yanxia Chen ^4B , Xiaolu Song ^5B , Sujie Zheng ^2C* , Jinlin Liu ^2AEG*

DOI: 10.12659/MSM.930241

Med Sci Monit 2021; 27:e930241

Table 5 Univariate analysis of secondary immunodeficiency in patients with multiple myeloma (MM) and matched MM patients.

Variable	Hazard ratio	95% Confidence interval	P value
Hypogammaglobulinemia (IgG	0.369	0.220–0.618
Sex (Male vs Female)	0.529	0.298–0.936	0.029
Age (≤65 years vs >65 years)	1.393	0.817–2.373	0.223
Calcium (normal vs abnormal) (141 cases available)	1.220	0.788–1.890	0.372
Hemoglobin (≤90 g/L vs >90 g/L) (145 cases available)	0.679	0.433–1.067	0.093
Creatinine (≤110 μmol/L vs>110 μmol/L)	1.447	0.873–2.399	0.152
Albumin (≤3.5 g/dL vs >3.5 g/dL) (146 cases available)	0.538	0.294–0.984	0.044
β-Microglobulin (≤3.5 mg/L vs >3.5 mg/L) (103 cases available)	0.834	0.628–1.108	0.210
Lactate dehydrogenase (≤250 U/L vs >250 U/L) (141 cases available)	1.046	0.418–2.619	0.923