13 April 2021>: Clinical Research
Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study
Yun Wang 1G , Liping Zhu 1D , Duo Xu 2F , Liying Gao 1C , Yongmei Li 1E , Baoquan Liang 1BC , Xiaoqian Zhang 1B , Yongfei Yue 1AC*DOI: 10.12659/MSM.930176
Med Sci Monit 2021; 27:e930176
Table 3 Multivariate linear regression analysis between total bile acid (TBA) and clinical characteristics.
Variable | β (95% confidence interval) | SE | p-Value |
---|---|---|---|
Age at delivery(years) | −0.034 (−0.041 to−0.026) | 0.004 | 0.203 |
BMI before pregnancy(kg/m) | 0.589 (0.577 to 0.601) | 0.006 | 0.063 |
Gravidity | 1.557 (1.521 to 1.592) | 0.018 | 0.201 |
Parity | −1.790 (−1.876 to −1.704) | 0.044 | 0.161 |
GA at delivery (week) | −1.608 (−1.632 to −1.584) | 0.012 | 0.072 |
CG (μmol/L) | 0.435 (0.432 to 0.437) | 0.001 | p |
ALT (U/L) | 0.092 (0.091 to 0.093) | 0.001 | p |
AST (U/L) | 0.064 (0.063 to 0.065) | 0.001 | p |
TB (μmol/L) | 1.326 (1.231 to 1.420) | 0.048 | p |
CB (μmol/L) | −0.071 (−0.167 to 0.025) | 0.049 | 0.149 |
UCB (μmol/L) | −1.092 (−1.186 to −0.998) | 0.048 | 0.061 |
TC (mmol/L) | 1.361 (1.338 to 1.383) | 0.011 | p |
TG (mmol/L) | 0.263 (0.260 to 0.266) | 0.015 | 0.306 |
iNOS (pg/ml) | −0.505 (−0.597 to −0.414) | 0.047 | p |
Birth weight (g) | −0.006 (−0.007 to −0.006) | 0.001 | 0.130 |
Placnetal weight (g) | 0.003 (0.003 to 0.004) | 0.001 | 0.392 |
1 min | −0.879 (−0.925 to−0.832) | 0.024 | p |
5 min | −0.315 (−0.389 to −0.241) | 0.038 | p |
BMI – body mass index; GA – gestational age; TBA – total bile acid; CG – cholyglycine; ALT – alanine transaminase; AST – aspartate transaminase; TB – total bilirubin; TG – triglyceride; TC – total cholesterol; CB – conjugated bilirubin; UCB – unconjugated bilirubin. |