Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study

13 April 2021: Clinical Research

Yun Wang ^1G , Liping Zhu ^1D , Duo Xu ^2F , Liying Gao ^1C , Yongmei Li ^1E , Baoquan Liang ^1BC , Xiaoqian Zhang ^1B , Yongfei Yue ^1AC*

DOI: 10.12659/MSM.930176

Med Sci Monit 2021; 27:e930176

Table 2 Bivariate correlation between inducible nitric oxide synthase (iNOS) levels and other variables.

iNOS	Normal		ICP
	r	p-Value	r	p-Value
Age at delivery (years)	0.029	p	0.085	p
BMI before pregnancy (kg/m)	−0.040	p	0.066	p
Gravidity	0.145	p	0.083	p
Parity	0.028	p	0.172	p
GA at delivery (week)	−0.157	p	0.046	p
TBA (μmol/L)	−0.227	p	−0.514	p
CG (μmol/L)	−0.204	p	−0.437	p
ALT (U/L)	−0.273	p	−0.327	p
AST (U/L)	−0.324	p	−0.432	p
TB (μmol/L)	−0.122	p	−0.101	p
CB (μmol/L)	−0.223	p	−0.029	p
UCB (μmol/L)	−0.005	0.021	−0.137	p
TC (mmol/L)	0.032	p	−0.049	p
TG (mmol/L)	−0.150	p	−0.008	p
Birth weight (g)	0.286	p	0.176	p
Placnetal weight (g)	0.214	p	0.246	p

1 min	0.121	p	0.204	p
5 min	0.313	p	0.196	p
BMI – body mass index; GA – gestational age; TBA – total bile acid, CG – cholyglycine; ALT – alanine transaminase; AST – aspartate transaminase; TB – total bilirubin; TG – triglyceride; TC – total cholesterol; CB – conjugated bilirubin; UCB – unconjugated bilirubin.