Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study

13 April 2021: Clinical Research

Yun Wang ^1G , Liping Zhu ^1D , Duo Xu ^2F , Liying Gao ^1C , Yongmei Li ^1E , Baoquan Liang ^1BC , Xiaoqian Zhang ^1B , Yongfei Yue ^1AC*

DOI: 10.12659/MSM.930176

Med Sci Monit 2021; 27:e930176

Table 1 Clinical characteristics of women with intrahepatic cholestasis of pregnancy (ICP) and normal pregnancies.

Parameter (mean±SD)	Normal (n=80)	ICP (n=77)	p-Value
Age at delivery (years)	28.97±4.43	28.62±4.48	NS
BMI before pregnancy (kg/m)	26.35±2.27	24.81±3.29	NS
Gravidity	1.96±1.07	2.05±1.06	NS
Parity	1.30±0.46	1.24±0.43	NS
GA at delivery (week)	38.70±1.31	37.21±1.47	p
TBA (μmol/L)	6.89±1.82	29.71±19.04	p
CG (μmol/L)	9.40±3.95	27.50±18.20	p
ALT (U/L)	28.19±10.24	72.90±67.09	p
AST (U/L)	24.35±12.57	84.22±70.07	p
TB (μmol/L)	9.09±3.43	14.88±7.44	p
CB (μmol/L)	2.51±1.90	4.45±3.62	p
UCB (μmol/L)	6.65±2.32	10.40±4.76	p
TC	4.30±1.30	5.97±1.68	p
TG	2.21±1.03	3.12±1.32	p
iNOS (pg/ml)	3073.77±457.16	2337.70±483.46	p
Rate of caesarean section	18.75%	48.05%	p
Birth weight (g)	3386.97±412.03	3120.10±413.52	p
Placnetal weight (g)	518.99±61.42	478.44±77.23	p

1 min	10 (10, 10)	9 (9, 10)	p
5 min	10 (10, 10)	9 (9, 10)	p
FIUD	3.75%	12.99%	0.034
Preterm delivery	5.00%	16.88%	0.021
IUGR	3.75%	14.29%	0.025
Neonatal unit admission	8.75%	16.56%	0.009
BMI – body mass index; GA – Gestational age; TBA – total bile acid; CG – Cholyglycine, ALT – alanine transaminase; AST – aspartate transaminase; TB – total bilirubin; CB – conjugated bilirubin; UCB – unconjugated bilirubin; TC – total cholesterol; TG – triglyceridel FIUD – fetal distress in uterus; IUGR – intrauterine growth retardation. Results are expressed as mean±standard error of the mean. APGAR Scores were expressed as median (interquartile range).