Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

Feiya Jiang; Tongtong Wang; Sha Li; Yu Jiang; Zhuo Chen; Wen Liu

doi:10.12659/MSM.930166

01 April 2021: Animal Study

Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

Feiya Jiang ^1AE , Tongtong Wang ^1B , Sha Li ^2D , Yu Jiang ^3C , Zhuo Chen ^4F , Wen Liua ^1AG*

DOI: 10.12659/MSM.930166

Med Sci Monit 2021; 27:e930166

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Table 1 Identification of significantly different metabolites from control, PQ, and PQ+AKF-PD groups by UPLC-QTOF-MS.

No	m/z	Metabolite	Formula	VIP	Fold change (control/PQ)	Fold change (PQ+ AKF-PD/PQ)	Pathway involved
1	134.09	Malic acid	C4H6O5	1.13074	2.5447^↑	1.6942↓^*	Amino sugar and nucleotide sugar metabolism
2	208.21	L-Kynurenine	C10H12N2O3	1.11808	1.41978^↑	0.61965^↑	Tyrosine metabolism
3	307.33	Glutathione	C10H17N3O6S	1.03463	0.0584↓^*	2.2952^↑	Glutathione metabolism
4	495.33	LysoPC160	CHNOP	1.18742	1.8909^↑	1.5564^↑	Glycerophospholipid metabolism
5	250.29	Ubiquinone-1	C14H18O4	1.14904	1.8712^↑	1.8611^↑
6	282.5	Oleic acid	C18H34O2	1.18412	1.5532^↑	0.48813↓^*	Biosynthesis of unsaturated fatty acids
7	95.979	Phosphoric acid	HO4P-2	1.09284	0.5675↓^*	0.82607↓^*
8	284.4	Retinal	C20H28O	1.17126	0.5198↓^*	1.5389^↑	Retinol metabolism
9	276.14	6-Phosphogluconic acid	C6H13O10P	1.64293	1.514↓^*	0.2113↓^*	Pentose phosphate pathway
10	204.22	Tryptophan	C11H12N2O2	1.34319	0.1111↓^*	1.3933^↑	Tryptophan metabolism
11	310.5	11Z-Eicosenoic acid	C20H38O2	1.40242	0.1408↓^*	1.3846^↑	Biosynthesis of unsaturated fatty acids
12	302.5	Retinyl ester	C20H30O2	1.17126	0.359↓^*	1.2502↓^*	Retinol metabolism
13	280.4	Linoleic acid	C18H32O2	1.31638	0.2517↓^*	1.97377^↑	Linoleic acid metabolism
14	476.6	Retinoyl b-glucuronide	C26H36O8	1.17126	0.2505↓^*	0.0379↓^*	Retinol metabolism
15	180.16	D-Galactose	C6H12O6	1.09284	1.2251^↑	0.97158↓^*	Galactose metabolism
16	130.1	Citraconic acid	C5H6O4	1.0432	1.135↓^*	0.937↓^*	Tricarboxylic acid cycle
17	178.21	Cysteinylglycine	C5H10N2O3S	1.47294	0.96835↓^*	1.01868^↑	Cysteine and methionine metabolism
18	188.23	Homo-L-arginine	C7H16N4O2	1.44482	1.0304^↑	0.7317↓^*	Arginine metabolism
^* The values were statistically significant (p ↑ The metabolites were up-regulated; ↓ The metabolites were down-regulated.

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Effect of Fluorofenidone Against Paraquat-Induced Pulmonary Fibrosis Based on Metabolomics and Network Pharmacology

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