10 May 2021: Clinical Research
Functional Magnetic Resonance Imaging of Language Following Constraint-Induced Aphasia Therapy Primed with Intermittent Theta Burst Stimulation in 13 Patients with Post-Stroke Aphasia
Jane B. Allendorfer 1BCDEF* , Rodolphe Nenert 1BCDE , Sangeeta Nair 1CDE , Jennifer Vannest 2ABDE , Jerzy P. Szaflarski 13ABCDEFGDOI: 10.12659/MSM.930100
Med Sci Monit 2021; 27:e930100
Table 3 Location and extent of functional magnetic resonance imaging (fMRI) activation in Figure 4. Brain regions showing differences in fMRI activation patterns between time points (T1, T2, T3) for the verb generation and verbal paired associates tasks are identified. Peak Montreal Neurologic Institute (MNI) coordinates (x, y, z) and t-value for each brain region are provided.
| Brain regions | Peak MNI coordinates | Peak t-value | Cluster extent (mm3) | |
|---|---|---|---|---|
| T2>T1 | R. AG ext. to R. IPL | +43, −71, +46 | 5.15 | 3429 |
| L./R. Pons | −11, −26, −35 | 5.36 | 2403 | |
| T3 | R. Cerebellum | +46, −59, −35 | −4.25 | 3240 |
| T2 | R./L. Cerebellum | +1, −56, −23 | −5.39 | 14,580 |
| Region ext. between R./L. MCG | +22, −26, +31 | −5.94 | 8154 | |
| Region ext. between R./L. SFG/SMA | +25, −2, +43 | −4.84 | 5913 | |
| Region ext. between R. Insula/ACC/MFG/SFG | +25, +25, +4 | −6.32 | 5157 | |
| R. LG | +19, −77, −5 | −3.90 | 3348 | |
| R. HC ext. to R. PHG, R. FG | +31, −26, −11 | −4.61 | 3321 | |
| R. Postcentral Gyrus | +58, −11, +34 | −3.85 | 3105 | |
| L. Calcarine Gyrus ext. to L. SOG | −23, −62, +7 | −5.44 | 2916 | |
| R. MTG | +52, −62, +1 | −4.13 | 2889 | |
| L. FG ext. to L. PHG, L. HC | −29, −29, −23 | −4.51 | 2538 | |
| R./L. Calcarine Gyrus | +4, −86, −11 | −4.53 | 2214 | |
| T3 | L. Insula | −41, −2, −5 | −3.86 | 2430 |
| T3 | R. MTG ext. to R. STG, R. IPL, R. AG | +49, −56, +13 | −7.31 | 20,007 |
| R. LG ext. to R. Calcarine Gyrus | +16, −68, −8 | −6.43 | 8478 | |
| R. Postcentral Gyrus | +34, −32, +49 | −5.74 | 5427 | |
| L. Cerebellum | −38, −65, −29 | −4.39 | 5049 | |
| R. Pallidum ext. to R. Thalamus, R. Putamen, R. Insula | +26, −10, +4 | −4.58 | 4806 | |
| R. Cerebellum ext. to L. Cerebellum | +22, −56, −35 | −4.77 | 4590 | |
| R. MCG | +7, +22, +40 | −4.39 | 4347 | |
| R. MFG | +40, +28, +40 | −5.56 | 4320 | |
| L. MFG ext. to L. IFG | −48, +43, +22 | −3.81 | 3186 | |
| L. Cerebellum ext. to L. ITG | −38, −38, −35 | −6.29 | 3159 | |
| R. IFG | +55, +34, +13 | −4.81 | 2997 | |
| R. Temporal Pole | +55, +13, −17 | −4.52 | 2214 | |
| R. MCG | +1, −5, +43 | −7.21 | 2214 | |
| T3 < T2 | L. Precuneus | −14, −71, +31 | −5.35 | 3402 |
| R. FG ext. to R. PHG | +25, +1, −41 | −4.60 | 2889 | |
| R. SOG ext. to R. AG | +28, −65, +26 | −5.42 | 2835 | |
| L. ITG | −35, −2, −44 | −5.05 | 2538 | |
| L. SMA ext. to R. SMA | −5, +16, +58 | −5.93 | 2079 | |
| T3 < T1 | R. SPL ext. to R. Precuneus | +16, −68, +52 | −4.43 | 2160 |
| L. Precuneus ext. to L. SPL | −11, −68, +34 | −5.51 | 1863 | |
| L. – left; R. – right; ext. – extending; AG – Angular Gyrus; IPL – Inferior Parietal Lobule; MCG – Middle Cingulate Gyrus; SFG – Superior Frontal Gyrus; SMA – Supplementary Motor Area; ACC – Anterior Cingulate Cortex; MFG – Middle Frontal Gyrus; PHG – Parahippocampal Gyrus; LG – Lingual Gyrus; HC – Hippocampus; SOG – Superior Occipital Gyrus; MTG – Middle Temporal Gyrus; FG – Fusiform Gyrus; STG – Superior Temporal Gyrus; SPL – Superior Parietal Lobule; IFG – inferior frontal gyrus; ITG – Inferior Temporal Gyrus. | ||||