22 May 2021: Clinical Research
Association of Lymphocyte-to-Monocyte Ratio with Poststroke Depression in Patients with Acute Ischemic Stroke
Lining Chong 1ACDF , Lin Han 2ABDF , Ruqian Liu 1BDF , Guomei Ma 1BF , Hao Ren 1ABCDEF*DOI: 10.12659/MSM.930076
Med Sci Monit 2021; 27:e930076
Table 1 Clinical and demographic characteristics of patients with acute ischemic stroke (AIS) according to lymphocyte-to-monocyte ratio (LMR) tertiles.
| Variables | Total | LMR values on admission | p-Value | ||
|---|---|---|---|---|---|
| Tertile 1 (n=169)LMR >4.85 | Tertile 2 (n=169)LMR 2.96–4.85 | Tertile 3 (n=169)LMR <2.96 | |||
| Age(years), median (IQR) | 61.0 (55.0–74.0) | 59.0 (54.0–66.0) | 60.0 (52.5–70.0) | 71.0 (60.0–78.5) | |
| Gender (Male), n (%) | 338 (66.7) | 107 (63.3) | 122 (72.2) | 109 (64.5) | 0.171 |
| Marital status (married), n(%) | 500 (98.6) | 165 (97.6) | 167 (98.8) | 168 (99.4) | 0.363 |
| Admission to hospital (hours), median (IQR) | 15.0 (5.0–39.0) | 16.0 (6.0–24.0) | 13.0 (5.0–35.0) | 18.0 (5.0–48.0) | 0.336 |
| Education (years), median (IQR) | 8.0 (7.0–11.0) | 8.0 (6.5–11.0) | 8.0 (7.0–11.0) | 8.0 (7.0–11.0) | 0.965 |
| Smoking, n (%) | 252 (49.7) | 84 (49.7) | 82 (48.5) | 86 (50.9) | 0.910 |
| Alcohol drinking, n (%) | 224 (44.2) | 78 (46.2) | 71 (42.0) | 75 (44.4) | 0.744 |
| Hypertension, n (%) | 391 (77.1) | 129 (76.3) | 132 (78.1) | 130 (76.9) | 0.925 |
| Diabetes, n (%) | 125 (24.7) | 40 (23.7) | 41 (24.3) | 44 (26.0) | 0.871 |
| Hyperlipidemia, n (%) | 186 (36.7) | 66 (39.1) | 65 (38.5) | 55 (32.5) | 0.390 |
| AF, n (%) | 46 (9.1) | 13 (7.7) | 12 (7.1) | 21 (12.4) | 0.175 |
| CHD, n (%) | 126 (24.9) | 37 (21.9) | 37 (21.9) | 52 (30.8) | 0.093 |
| Stroke history, n (%) | 173 (34.1) | 50 (29.6) | 55 (32.5) | 68 (40.2) | 0.103 |
| Frontal lobe, n (%) | 89 (17.6) | 30 (17.8) | 28 (16.6) | 31 (18.3) | 0.909 |
| Parietal lobe, n (%) | 44 (8.7) | 15 (8.9) | 13 (7.7) | 16 (9.5) | 0.840 |
| Temporal lobe, n (%) | 34 (6.7) | 10 (5.9) | 11 (6.5) | 13 (7.7) | 0.802 |
| Occipital lobe, n (%) | 26 (5.1) | 9 (5.3) | 10 (5.9) | 7 (4.1) | 0.753 |
| Basal ganglia, n (%) | 211 (41.6) | 70 (41.4) | 68 (40.2) | 73 (43.2) | 0.857 |
| Midbrain, n (%) | 40 (7.9) | 11 (6.5) | 13 (7.7) | 16 (9.5) | 0.597 |
| Pons, n (%) | 50 (9.9) | 17 (10.1) | 15 (8.9) | 18 (10.7) | 0.856 |
| Medulla, n (%) | 44 (8.7) | 15 (8.9) | 13 (7.7) | 16 (9.5) | 0.840 |
| Cerebellum, n (%) | 51 (10.1) | 20 (11.8) | 16 (9.5) | 15 (8.9) | 0.633 |
| CRP (mg/L) | 10.45±2.26 | 10.02±1.35 | 10.55±2.10 | 10.78±1.63 | 0.865 |
| ESR (mm/h) | 12.66±3.25 | 12.39±2.56 | 12.86±3.51 | 13.43±2.28 | 0.129 |
| PCT (ng/ml) | 1.35±0.31 | 1.21±0.16 | 1.46±0.11 | 1.52±0.41 | 0.086 |
| NIHSS score, median (IQR) | 4.0 (2.0–8.0) | 2.0 (1.0–4.5) | 3.0 (2.0–6.0) | 8.0 (4.0–10.0) | |
| HAMD score, median (IQR) | 2 (1.0–8.0) | 2.0 (1.0–4.5) | 1.0 (0–7.5) | 5.0 (1.0–12.0) | |
| n – number of patients; AF – atrial fibrillation; CHD – coronary heart disease; CRP – C-reactive protein; ESR – erythrocyte sedimentation rate; PCT – procalcitonin; NIHSS – National Institutes of Health Stroke Scale; HAMD – Hamilton Depression Scale; LMR – lymphocyte-to-monocyte ratio. | |||||