17 April 2021>: Clinical Research
Epidemiology of 631 Cases of COVID-19 Identified in Jiangsu Province Between January 1 and March 20 2020: Factors Associated with Disease Severity and Analysis of Zero Mortality
Hong Ji 1AE* , Qigang Dai 1AC* , Hui Jin 2C* , Ke Xu 1C , Jing Ai 1F , Xinyu Fang 3E , Naiyang Shi 2C , Haodi Huang 1D , Ying Wu 1B , Zhihang Peng 3B , Jianli Hu 1C , Liguo Zhu 1F , Changjun Bao 14A* , Ming Wu 15AG*DOI: 10.12659/MSM.929986
Med Sci Monit 2021; 27:e929986
Table 2 Epidemiological and clinical characteristics of severe (n=53) and non-severe (n=578) cases with reported confirmed cases of coronavirus disease 2019 (COVID-19) by March 20, 2020, Jiangsu Province, Eastern China.
Variable | All patients (n=631) | Severe (n=53) | Non-severe (n=578) | P-value | Unadjusted OR (95% CI) |
---|---|---|---|---|---|
Male | 344 (54.5) | 35 (66.04) | 309 (53.46) | P=0.078 | 1.69 (0.94–3.06) |
Female | 287 (45.5) | 18 (33.96) | 269 (46.54) | ||
a | |||||
Median (IQR) | 46 (33–56) | 56 (48–68) | 44 (32–55) | P=0.000 | NA |
≤18 yrs | 21 (3.33) | 0 (0.00) | 21 (3.64) | P=0.000 | Reference |
19–40 yrs | 237 (37.56) | 7 (13.21) | 230 (39.79) | 0.64 (0.08–5.45) | |
41–64 yrs | 299 (47.39) | 28 (52.83) | 271 (46.88) | 2.17 (0.28–16.75) | |
≥65 yrs | 74 (11.73) | 18 (33.96) | 46 (9.69) | ||
Any | 195 (30.90) | 33 (62.26) | 162 (28.03) | P=0.000 | |
Hypertension | 98 (15.53) | 19 (35.85) | 79 (13.67) | P=0.000 | |
Diabetes | 38 (6.02) | 10 (18.87) | 28 (4.84) | P=0.000 | |
Cerebrovascular disease | 34 (5.39) | 10 (18.87) | 24 (4.15) | P=0.000 | |
Chronic obstructive pulmonary disease | 21 (3.33) | 4 (7.55) | 17 (2.94) | P=0.091 | 2.69 (0.87–8.32) |
Liver and renal disease | 21 (3.33) | 4 (7.55) | 17 (2.94) | P=0.074 | 2.69 (0.87–8.32) |
Pregnancy | 3 (0.48) | 1 (1.89) | 2 (0.35) | P=0.119 | 5.54 (0.49–62.11) |
The first generation infections | 277 (43.90) | 21 (39.62) | 256 (44.29) | Reference | |
The second generation infections | 154 (24.41) | 18 (33.96) | 136 (23.53) | P=0.365 | 1.67 (0.92–3.05) |
The third generation infections | 196 (31.06) | 14 (26.42) | 182 (31.49) | 0.87 (0.46–1.64) | |
Stage 1 | 21 (3.33) | 4 (7.55) | 17 (2.94) | ||
Stage 2 | 236 (37.40) | 25 (47.17) | 211 (36.51) | ||
Stage 3 | 236 (37.40) | 19 (35.85) | 217 (37.54) | 1.35 (0.72–2.53) | |
Stage 4 | 138 (21.87) | 5 (9.43) | 133 (23.01) | Reference | |
Urban | 328 (51.98) | 36 (67.93) | 292 (50.52) | P=0.015 | 2.07 (1.14–3.78) |
Rural | 303 (48.02) | 17 (32.08) | 286 (49.48) | ||
≤1 days | 325 (55.56) | 21 (40.39) | 304 (57.04) | P=0.021 | |
≤3 days | 331 (52.79) | 21 (39.62) | 310 (54.01) | P=0.045 | |
≤7 days | 364 (57.69) | 25 (47.17) | 339 (58.65) | P=0.105 | 0.63 (0.36–1.11) |
486 (77.02) | 48 (90.57) | 438 (75.79) | P=0.016 | ||
30 (6.34) | 0 (0.00) | 30 (6.96) | P=0.000 | 0.35 (0.05–2.58) | |
37.3–38.0°C | 239 (50.53) | 13 (30.95) | 226 (52.44) | ||
38.01–39.0°C | 165 (34.88) | 19 (45.24) | 146 (33.87) | 1.65 (0.92–2.99) | |
>39.0°C | 39 (8.25) | 10 (23.81) | 29 (6.73) | ||
Cough | 212 (33.60) | 17 (32.08) | 195 (33.74) | P=0.806 | 0.93 (0.51–1.69) |
Expectoration | 135 (21.39) | 15 (28.30) | 120 (20.76) | P=0.200 | 1.51 (0.80–2.83) |
Fatigue | 132 (20.92) | 15 (28.30) | 117 (20.24) | P=0.167 | 1.56 (0.83–2.92) |
Chill | 81 (12.84) | 13 (24.53) | 68 (11.76) | P=0.008 | |
Myalgia/arthralgia | 79 (12.52) | 9 (16.98) | 70 (12.11) | P=0.305 | 1.48 (0.70–3.17) |
Headache | 74 (11.72) | 8 (15.09) | 66 (11.42) | P=0.426 | 1.38 (0.62–3.05) |
Sore throat | 58 (9.19) | 5 (9.43) | 53 (9.17) | P=1.000 | 1.03 (0.39–2.70) |
Runny nose | 49 (7.77) | 1 (1.89) | 48 (8.30) | P=0.161 | 0.21 (0.03–1.57) |
Chest tightness | 42 (6.06) | 10 (18.87) | 32 (5.54) | P=0.001 | |
Diarrhea | 36 (5.71) | 4 (7.55) | 32 (5.54) | P=0.768 | 1.39 (0.47–4.10) |
Nasal congestion | 32 (5.07) | 1 (1.89) | 31 (5.36) | P=0.604 | 0.34 (0.05–2.54) |
Dyspnea | 25 (2.06) | 11 (20.75) | 14 (2.42) | P=0.000 | |
Vomit | 13 (2.06) | 2 (3.77) | 11 (1.90) | P=0.680 | 2.02 (0.44–9.37) |
a | |||||
Median(IQR) | 5.02 (4.00–6.18) | 5.1 (4.00–6.28) | 5.01 (4.00–6.11) | P=0.406 | NA |
136 (24.03) | 11 (23.91) | 125 (24.04) | P=0.383 | 1.00 (0.49–2.01) | |
4–10 | 419 (74.03) | 33 (71.74) | 386 (74.23) | 0.88 (0.45–1.72) | |
>10 | 11 (1.94) | 2 (4.35) | 9 (1.73) | 2.58 (0.54–12.32) | |
a | |||||
Median(IQR) | 1.23 (0.92–1.67) | 1.00 (0.75–1.37) | 1.27 (0.94–1.71) | P=0.491 | |
173 (28.88) | 29 (56.86) | 144 (26.28) | P=0.000 | ||
≥1.0 | 426 (71.12) | 22 (43.14) | 404 (73.72) | ||
Data are% (n/N), NA – not available, Among the 631 COVID-19 cases,578 non-severe cases including 129 patients (20.4%) diagnosed with mild without pneumonia, 449 patients (71.2%) with mild with pneumonia, 53 severe cases including 45 patients (7.1%) with severe pneumonia, and 8 patients (1.3%) with critically ill. Pearson Chi-square test was used, a is for independent samples t test. |