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17 April 2021: Clinical Research

Epidemiology of 631 Cases of COVID-19 Identified in Jiangsu Province Between January 1 and March 20 2020: Factors Associated with Disease Severity and Analysis of Zero Mortality

Hong Ji 1AE* , Qigang Dai 1AC* , Hui Jin 2C* , Ke Xu 1C , Jing Ai 1F , Xinyu Fang 3E , Naiyang Shi 2C , Haodi Huang 1D , Ying Wu 1B , Zhihang Peng 3B , Jianli Hu 1C , Liguo Zhu 1F , Changjun Bao 14A* , Ming Wu 15AG*

DOI: 10.12659/MSM.929986

Med Sci Monit 2021; 27:e929986

Table 2 Epidemiological and clinical characteristics of severe (n=53) and non-severe (n=578) cases with reported confirmed cases of coronavirus disease 2019 (COVID-19) by March 20, 2020, Jiangsu Province, Eastern China.

VariableAll patients (n=631)Severe (n=53)Non-severe (n=578)P-valueUnadjusted OR (95% CI)
Male344 (54.5)35 (66.04)309 (53.46)P=0.0781.69 (0.94–3.06)
Female287 (45.5)18 (33.96)269 (46.54)
a
Median (IQR)46 (33–56)56 (48–68)44 (32–55)P=0.000NA
≤18 yrs21 (3.33)0 (0.00)21 (3.64)P=0.000Reference
19–40 yrs237 (37.56)7 (13.21)230 (39.79)0.64 (0.08–5.45)
41–64 yrs299 (47.39)28 (52.83)271 (46.88)2.17 (0.28–16.75)
≥65 yrs74 (11.73)18 (33.96)46 (9.69)
Any195 (30.90)33 (62.26)162 (28.03)P=0.000
Hypertension98 (15.53)19 (35.85)79 (13.67)P=0.000
Diabetes38 (6.02)10 (18.87)28 (4.84)P=0.000
Cerebrovascular disease34 (5.39)10 (18.87)24 (4.15)P=0.000
Chronic obstructive pulmonary disease21 (3.33)4 (7.55)17 (2.94)P=0.0912.69 (0.87–8.32)
Liver and renal disease21 (3.33)4 (7.55)17 (2.94)P=0.0742.69 (0.87–8.32)
Pregnancy3 (0.48)1 (1.89)2 (0.35)P=0.1195.54 (0.49–62.11)
The first generation infections277 (43.90)21 (39.62)256 (44.29)Reference
The second generation infections154 (24.41)18 (33.96)136 (23.53)P=0.3651.67 (0.92–3.05)
The third generation infections196 (31.06)14 (26.42)182 (31.49)0.87 (0.46–1.64)
Stage 121 (3.33)4 (7.55)17 (2.94)
Stage 2236 (37.40)25 (47.17)211 (36.51)
Stage 3236 (37.40)19 (35.85)217 (37.54)1.35 (0.72–2.53)
Stage 4138 (21.87)5 (9.43)133 (23.01)Reference
Urban328 (51.98)36 (67.93)292 (50.52)P=0.0152.07 (1.14–3.78)
Rural303 (48.02)17 (32.08)286 (49.48)
≤1 days325 (55.56)21 (40.39)304 (57.04)P=0.021
≤3 days331 (52.79)21 (39.62)310 (54.01)P=0.045
≤7 days364 (57.69)25 (47.17)339 (58.65)P=0.1050.63 (0.36–1.11)
486 (77.02)48 (90.57)438 (75.79)P=0.016
30 (6.34)0 (0.00)30 (6.96)P=0.0000.35 (0.05–2.58)
37.3–38.0°C239 (50.53)13 (30.95)226 (52.44)
38.01–39.0°C165 (34.88)19 (45.24)146 (33.87)1.65 (0.92–2.99)
>39.0°C39 (8.25)10 (23.81)29 (6.73)
Cough212 (33.60)17 (32.08)195 (33.74)P=0.8060.93 (0.51–1.69)
Expectoration135 (21.39)15 (28.30)120 (20.76)P=0.2001.51 (0.80–2.83)
Fatigue132 (20.92)15 (28.30)117 (20.24)P=0.1671.56 (0.83–2.92)
Chill81 (12.84)13 (24.53)68 (11.76)P=0.008
Myalgia/arthralgia79 (12.52)9 (16.98)70 (12.11)P=0.3051.48 (0.70–3.17)
Headache74 (11.72)8 (15.09)66 (11.42)P=0.4261.38 (0.62–3.05)
Sore throat58 (9.19)5 (9.43)53 (9.17)P=1.0001.03 (0.39–2.70)
Runny nose49 (7.77)1 (1.89)48 (8.30)P=0.1610.21 (0.03–1.57)
Chest tightness42 (6.06)10 (18.87)32 (5.54)P=0.001
Diarrhea36 (5.71)4 (7.55)32 (5.54)P=0.7681.39 (0.47–4.10)
Nasal congestion32 (5.07)1 (1.89)31 (5.36)P=0.6040.34 (0.05–2.54)
Dyspnea25 (2.06)11 (20.75)14 (2.42)P=0.000
Vomit13 (2.06)2 (3.77)11 (1.90)P=0.6802.02 (0.44–9.37)
a
Median(IQR)5.02 (4.00–6.18)5.1 (4.00–6.28)5.01 (4.00–6.11)P=0.406NA
136 (24.03)11 (23.91)125 (24.04)P=0.3831.00 (0.49–2.01)
4–10419 (74.03)33 (71.74)386 (74.23)0.88 (0.45–1.72)
>1011 (1.94)2 (4.35)9 (1.73)2.58 (0.54–12.32)
a
Median(IQR)1.23 (0.92–1.67)1.00 (0.75–1.37)1.27 (0.94–1.71)P=0.491
173 (28.88)29 (56.86)144 (26.28)P=0.000
≥1.0426 (71.12)22 (43.14)404 (73.72)
Data are% (n/N), NA – not available, Among the 631 COVID-19 cases,578 non-severe cases including 129 patients (20.4%) diagnosed with mild without pneumonia, 449 patients (71.2%) with mild with pneumonia, 53 severe cases including 45 patients (7.1%) with severe pneumonia, and 8 patients (1.3%) with critically ill. Pearson Chi-square test was used,
a is for independent samples t test.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750