Association of Blood Pressure, White Matter Lesions, and Regional Cerebral Blood Flow

21 June 2021: Clinical Research

Dong Zhang ^1ABCDEF , Jianyu Zhang ^1CEF , Bo Zhang ^2ABD , Jin Zhang ^1BDE , Mingli He ^1ABDEG*

DOI: 10.12659/MSM.929958

Med Sci Monit 2021; 27:e929958

Table 2 Logistics regression analysis of Fazekas grades and various factors.

Variables	Univariate		Multivariate
Variables	OR (95% CI)	P value	OR(95%CI)	P value
Age	1.102 (1.050–1.157)		1.089 (1.034–1.147)	0.001
BMI	0.891 (0.811–0.979)	0.016	0.889 (0.792–0.997)	0.045
24hMSBP	1.099 (1.052–1.149)		1.085 (1.029–1.145)	0.003
24hMDBP	1.053 (1.001–1.107)	0.045	1.075 (1.006–1.147)	0.031
MDSBP	1.067 (1.026–1.110)	0.001	1.066 (1.021–1.112)	0.004
MNSBP	1.110 (1.063–1.159)		1.112 (1.059–1.169)
MDDBP	1.027 (0.978–1.077)	0.285	1.055 (0.998–1.115)	0.059
MNDBP	1.075 (1.025–1.127)	0.003	1.087 (1.030–1.147)	0.002
SBPDNR	0.822 (0.753–0.897)		0.801 (0.711–0.902)
DBPDNR	0.906 (0.854–0.961)	0.001	0.876 (0.807–0.950)	0.001
MSCBF (F3)	1.000	–	1.000	–
F2	1.338 (1.158–1.545)		1.433 (1.186–1.732)
F1	1.654 (1.393–1.963)		1.812 (1.456–2.254)
F0	1.799 (1.504–2.150)		1.976 (1.576–2.477)
MPCBF (F3)	1.000	–	1.000	–
F2	1.313 (1.133–1.522)		1.352 (1.129–1.618)	0.001
F1	1.757 (1.447–2.133)		1.877 (1.486–2.372)
F0	1.900 (1.556–2.319)		2.034 (1.602–2.583)
MDSBP – daytime mean systolic blood pressure; MNSBP – mean systolic blood pressure at night; MDDBP – daytime mean diastolic blood pressure; MNDBP – mean diastolic pressure at night; 24hSBP – 24-hour mean systolic blood pressure; 24hDBP – 24-hour mean diastolic blood pressure; SBPDNR – systolic blood pressure ratio between day and night; DBPDNR – diastolic blood pressure day/night ratio; MSCBF: bilateral mean subcortical local cerebral blood flow; MPCBF – bilateral mean paraventricular cerebral blood flow; F – Fazekas grade.