21 June 2021: Clinical Research
Association of Blood Pressure, White Matter Lesions, and Regional Cerebral Blood Flow
Dong Zhang 1ABCDEF , Jianyu Zhang 1CEF , Bo Zhang 2ABD , Jin Zhang 1BDE , Mingli He 1ABDEG*DOI: 10.12659/MSM.929958
Med Sci Monit 2021; 27:e929958
Table 1 Comparison of background data of patients based on 24h mean SBP quartile grouping.
| Variables | Q1 (100–127) | Q2 (128–133) | Q3 (134–139) | Q4 (140–169) | P value |
|---|---|---|---|---|---|
| n | 39 | 31 | 35 | 30 | |
| Age (Year, M, IQR) | 65 (58–72) | 66 (64–74) | 69 (64–74) | 69.5 (63.8–75) | 0.067* |
| Male (n, %) | 22, 56.4 | 13, 41.9 | 19, 54.3 | 14, 46.7 | 0.929*** |
| Culture above junior high school (n, %) | 23, 59.0 | 17, 54.8 | 16, 45.7 | 10, 33.3 | 0.101*** |
| BMI (kg/m, m±s) | 25.43±3.32 | 25.73±3.89 | 23.51±3.53 | 26.16±3.86 | 0.195** |
| Hypertension (n, %) | 27, 69.2 | 31, 100.0 | 34, 97.1 | 30, 100.0 | 0.002*** |
| Dyslipidemia (n, %) | 8, 20.5 | 11, 34.5 | 8, 22.9 | 11, 36.7 | 0.788*** |
| Diabetes (n, %) | 9, 23.1 | 7, 22.6 | 8, 22.9 | 14, 46.7 | 0.156*** |
| Coronary heart disease (n, %) | 9, 23.1 | 6, 19.4 | 7, 20.0 | 4, 13.3 | 0.507*** |
| Fasting blood glucose (mmol/L, M, IQR) | 5.06 (4.65–5.90) | 5.23 (4.87–6.78) | 5.18 (4.88–6.26) | 5.38 (4.89–7.50) | 0.184* |
| Smoke (n, %) | 8, 20.5 | 5, 16.1 | 8, 22.9 | 7, 23.3 | 0.519*** |
| Drinking (n, %) | 8, 20.5 | 5, 16.1 | 8, 22.9 | 8, 26.7 | 0.393*** |
| SBP on admission (mmHg, m±s) | 132.2±18.5 | 144.8±12.2 | 149.4±11.6 | 158.4±17.7 | ** |
| DBP on admission (mmHg, m±s) | 79.6±11.8 | 83.9±12.1 | 87.1±9.6 | 89.9±13.0 | 0.001* |
| Cholesterol (mmol/L, m±s) | 3.96±1.42 | 4.72±1.31 | 4.34±1.16 | 4.65±0.94 | 0.391** |
| Triglyceride (mmol/L, M, IQR) | 1.17 (0.87–1.49) | 1.42 (0.88–1.78) | 1.26 (0.86–1.70) | 1.27 (0.88–1.80) | 0.507* |
| LDL-C (mmol/L, m±s) | 2.19±0.88 | 2.67±0.76 | 2.35±0.76 | 2.47±0.61 | 0.942** |
| HDL-C (mmol/L, M, IQR) | 1.00 (0.86–1.17) | 1.08 (0.97–1.28) | 1.07 (0.94–1.33) | 1.05 (0.92–1.18) | 0.430* |
| 24hMDBP (mmHg, m±s) | 71.7±5.6 | 78.4±5.9 | 80.1±5.2 | 83.7±5.2 | ** |
| MDSBP (mmHg, m±s) | 122.8±8.5 | 133.6±3.0 | 137.7±3.6 | 147.2±5.6 | * |
| MNSBP (mmHg, m±s) | 113.2±9.5 | 125.4±3.7 | 132.9±4.8 | 142.6±9.8 | * |
| MDDBP (mmHg, m±s) | 74.5±6.5 | 81.2±5.7 | 82.2±5.8 | 85.1±5.8 | * |
| MNDBP (mmHg, m±s) | 67.5±6.3 | 74.7±6.1 | 76.2±5.7 | 81.3±6.1 | ** |
| SBPDNR (%, M, IQR) | 9.63±2.71 | 9.69±1.87 | 10.29±2.22 | 10.27±2.61 | 0.130** |
| DBPDNR (%, M, IQR) | 10.19±3.00 | 10.99±2.74 | 10.93±2.93 | 11.35±3.15 | 0.083* |
| SBPCV (m±s) | 7.79±5.92 | 6.02±4.00 | 3.37±5.40 | 3.04±6.70 | * |
| DBPCV (m±s) | 9.27±6.20 | 7.99±5.53 | 7.09±6.20 | 4.17±7.67 | 0.023* |
| MSCBF (ml/100G/Min, m±s) | 46.31±11.37 | 41.53±13.37 | 37.32±13.48 | 33.19±7.22 | * |
| MPCBF (ml/100G/Min, m±s) | 51.16±15.06 | 43.63±13.85 | 38.17±14.10 | 36.11±9.40 | * |
| Fazekas score (m±s) | 1.18±1.35 | 1.32±1.05 | 2.54±1.87 | 3.13±1.57 | * |
| MoCA (M, IQR) | 22 (19–24) | 21 (17–24) | 17 (12–21) | 15.5 (11.8–20.3) | * |
| * Man-Whitney test; ** independent sample -test; *** Pearson Chi-square test; Q1-q4 – CV is grouped according to the quartile of population; m – median; IQR – interquartile spacing; m±s – mean±standard deviation; LDL-C – low density lipoprotein cholesterol; HDL-C – high-density lipoprotein cholesterol; MDSBP – daytime mean systolic blood pressure; MNSBP – mean systolic blood pressure at night; MDDBP – daytime mean diastolic blood pressure; MNDBP – mean diastolic pressure at night; SBPCV – coefficient of variation of 24-hour systolic blood pressure; DBPCV – 24-hour diastolic blood pressure variation coefficient; SBPDNR – systolic blood pressure ratio between day and night; DBPDNR – diastolic blood pressure day/night ratio; MSCBF – bilateral mean subcortical local cerebral blood flow; MPCBF – bilateral mean paraventricular cerebral blood flow; MoCA – Monterey Cognitive Assessment Scale. | |||||