08 February 2021: Clinical Research
Diagnosis of Prostate Cancer in Patients with Prostate-Specific Antigen (PSA) in the Gray Area: Construction of 2 Predictive Models
Ming Chen 1BCE* , Ting Ma 1CDE* , Jun Li 1AEG* , Hai-Jun Zhang 2D , Qiang Li 3F , Jia-Jia Wang 1F , Tian Sang 1B , Chun-Li Cao 1D , Xin-Wu Cui 4AEF*DOI: 10.12659/MSM.929913
Med Sci Monit 2021; 27:e929913
Table 1 Characteristics of clinical information for enrolled patient.
| Parameter | All enrolled patients | Patients with PCa | |||||
|---|---|---|---|---|---|---|---|
| BPH group (n=109) | PCa group (n=72) | P | NCS-PCa group (n=44) | CS-PCa group (n=28) | P | ||
| Age (years) | 74.00 (66.00, 77.00) | 76.00 (69.00, 79.00) | 0.07a | 76.00 (69.00, 78.00) | 75.50 (66.50, 79.00) | 0.86a | |
| tPSA (ng/ml) | 6.91±1.35 | 7.25±1.47 | 0.12b | 7.14±1.64 | 7.42±1.18 | 0.44b | |
| f/t PSA | 0.21±0.12 | 0.15±0.06 | c | 0.14±0.07 | 0.15±0.04 | 0.57c | |
| PSAD (ng/ml·cm) | 0.14 (0.07, 0.19) | 0.19 (0.12, 0.25) | a | 0.15±0.08 | 0.24±0.05 | c | |
| DRE [No. (%)]d | Positive | 3 (2.75) | 7 (9.72) | 0.09 | 3 (6.82) | 4 (14.29) | 0.53 |
| Negative | 106 (97.25) | 65 (90.28) | 41 (93.18) | 24 (85.71) | |||
| TRUS [No. (%)]e | Positive | 21 (19.27) | 14 (19.44) | 0.72 | 8 (18.18) | 6 (21.43) | 0.82 |
| Suspicious | 38 (34.86) | 29 (40.28) | 17 (38.64) | 12 (42.86) | |||
| Negative | 50 (45.87) | 29 (40.28) | 19 (43.18) | 10 (35.71) | |||
| mpMRI [No. (%)]e | Positive | 16 (14.67) | 29 (40.28) | 11 (25.00) | 15 (53.57) | 0.01 | |
| Suspicious | 15 (13.76) | 16 (22.22) | 10 (22.73) | 8 (28.57) | |||
| Negative | 78 (71.57) | 27 (37.50) | 23 (52.27) | 5 (17.86) | |||
| PCa – prostate cancer; NCS-PCa – nonclinically significant prostate cancer; CS-PCa – clinically significant prostate cancer; PSA – prostate-specific antigen; tPSA – total PSA; f/t PSA – free/total PSA; PSAD – PSA density; DRE – digital rectal examination; TRUS – transrectal ultrasound; mpMRI – multiparametric magnetic resonance imaging. a These parameters were presented as median (interquartile range) and analyzed by Mann-Whitney U test; b These parameters were performed as means±standard deviations and analyzed by two-sample t-test; c These parameters were performed as means±standard deviations and analyzed by separate variance estimation t-test; d These parameters were analyzed by Continuity Correction test; e These parameters were analyzed by Chi-Square test. | |||||||