Type of Necrosis Influences Prognosis in Hepatocellular Carcinoma After the First Transarterial Chemoembolization

10 May 2021: Clinical Research

Zhi-Juan Wu ^1BCDE , Yin-Fa Xie ^2B , Xu Chang ^2BCD , Lin Zhang ^2AE* , Hui-Yong Wu ^2B , Ji-Bing Liu ^2B , Jian-Xin Zhang ^2C , Peng Sun ^2C

DOI: 10.12659/MSM.929884

Med Sci Monit 2021; 27:e929884

Table 4 Univariate and multivariate analyses of the factors affecting overall survival.

Parameter	Univariate analysis			Multivariate analysis
Parameter	Hazard ratio	95% CI	P value	Hazard ratio	95% CI	P value
Necrosis type (liquefactive/coagulative)	0.623	0.450–0.863	0.004	0.596	0.426–0.834	0.003
Sex (Male/Female)	1.354	0.823–2.226	0.231
Age (>60 years/	1.232	0.879–1.727	0.226
Hepatitis (present/absent)	0.944	0.604–1.474	0.799
Liver cirrhosis (present/absent)	0.607	0.439–0.840	0.002	0.664	0.471–0.936	0.019
Child-Pugh classification (B/A)	0.194	0.126–0.300	0.000	0.210	0.134–0.329	0.000
Barcelona Clinic Liver Cancer (stage C/stage B)	0.780	0.510–1.193	0.250
Maximum diameter (>10 cm/	0.942	0.683–1.299	0.715
Pseudocapsule (present/absent)	0.994	0.702–1.408	0.972
Alpha-fetoprotein (>400 ng/ml/	0.793	0.571–1.099	0.163
Location (left lobe/right lobe)	0.698	0.486–1.005	0.052	0.675	0.461–0.989	0.044
Portal vein tumor thrombus (present/absent)	0.700	0.501–0.978	0.036	0.910	0.629–1.315	0.615
Arteriovenous fistula (present/absent)	0.624	0.421–0.925	0.018	0.729	0.481–1.104	0.136
Other treatments (present/absent)	0.757	0.512–1.121	0.163
CI – confidence interval.