Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model

Yiming Zhang; Miaomiao Ma; Jun Li; Yingye Wu; Lu Xue; Rongrong Zhao; Lu Wang; Shuping Hou; Huiping Wang

doi:10.12659/MSM.929781

05 June 2021: Animal Study

Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model

Yiming Zhang ^1A* , Miaomiao Ma ^2A* , Jun Li ^3D , Yingye Wu ^2C , Lu Xue ^2C , Rongrong Zhao ^2B , Lu Wang ^2E , Shuping Hou ^2G* , Huiping Wang ^2G*

DOI: 10.12659/MSM.929781

Med Sci Monit 2021; 27:e929781

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Table 2 Comparison of ear pinna thickness.

Group	Ear thickness (μm)
Group	Day 2	Day 4	Day 6	Day 8
Control	19.15±0.26	19.15±0.26	19.15±0.26	19.15±0.26
IMQ	24.95±1.74	34.48±1.45	38.90±1.79	43.8±1.44
IM-PBS	24.25±1.51	32.82±1.63	37.69±1.63	42.5±1.78
IM-pGP3	23.60±1.30	30.72±1.44	35.83±1.34^*	34.12±1.25^*
IM-pGP3M	23.92±1.42	31.36±1.48	34.54±1.29^*	33.76±1.59^*
IMQ – imiquimod; PBS – phosphate-buffered saline; IM – intramuscular. Ear thickness was significantly thinner in mice treated with pGP3 and pGP3M than in mice treated with PBS on Day 6 and Day 8. Results are shown as mean±SD. ^*

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Anti-Psoriatic Effects of Middle Fragment of Chlamydial Plasmid-Encoded Protein pGP3 in an Imiquimod-Induced Psoriasis Mouse Model

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