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24 January 2021: Clinical Research

Elevated Plasma Angiopoietinlike Protein 5 (ANGPTL5) Is More Positively Associated with Glucose Metabolism Disorders in Patients with Metabolic Syndrome

Chang Liu 123ABCD* , Xin Yi 123AEG* , Yongnan Lyu 123CF , Wei Ren 4CD , Yi Zhou 123BF , Gaoke Feng 123E , Weiguo Wan 123B , Xue-jun Jiang 123AEG*

DOI: 10.12659/MSM.929626

Med Sci Monit 2021; 27:e929626

Table 1 Demographic and clinical characteristics of subjects included.

Variablesnon-MS (n=70)MS (n=69)Total (n=139)P value
Age (years)54.96±17.0460.14±12.9157.52±15.300.045
Male (%)48.57%53.62%51.08%0.551
Smoking (%)51.43%49.28%50.36%0.800
Family history
 Diabetes (%)15.71%40.58%28.06%0.002
 Hypertension (%)65.71%62.32%64.03%0.677
Waist circumference (cm)
 Men84.38±2.8594.35±3.5289.58±5.94
 Women81.22±2.3489.56±4.0785.15±5.30
WHR0.82±0.050.98±0.080.90±0.10
BMI (kg/m)21.86±1.2227.04±2.7524.43±3.35
SBP (mmHg)127.47±11.81141.91±20.22134.64±10.27
DBP (mmHg)77.71±10.2675.14±10.2076.44±10.270.141
FPG (mmol/L)5.10 (5.00–5.30)6.80 (6.25–7.65)5.50 (5.10–6.80)
FINS (μU/ml)10.10 (9.08–11.60)11.90 (10.45–13.55)10.80 (9.40–12.60)
HbA1c (%)5.30 (5.10–5.50)5.90 (5.70–6.90)5.60 (5.30–5.90)
TC (mmol/L)4.02±0.634.82±0.904.42±0.87
TG (mmol/L)1.02 (0.78–1.41)1.77 (1.47–2.35)1.43 (0.96–1.81)
HDL-C (mmol/L)1.32±0.251.20±0.261.26±0.260.009
LDL-C (mmol/L)2.19±0.513.11±0.782.64±0.80
hs-CRP (mg/L)2.80 (1.85–3.63)3.90 (1.30–7.78)3.15 (1.50–4.43)0.006
BUN (mmol/L)4.92 (3.84–5.64)5.05 (4.32–6.05)4.99 (3.99±5.90)0.128
CREA (μmol/L)66.50 (55.00–81.25)69.00 (54.50–80.00)68.00 (55.00–81.00)0.893
URIC (μmol/L)264.43±59.78318.52±72.86291.28±71.69
TBIL (μmol/L)13.54±5.4814.13±5.2713.83±5.360.519
DBIL (μmol/L)4.71±2.264.27±1.954.49±2.120.251
IBIL (μmol/L)8.80±3.529.85±3.699.32±3.630.088
AST (U/L)15.00 (12.00–20.25)16.00 (13.00–20.00)16.00 (12.00–20.00)0.485
ALT (U/L)14.00 (10.00–20.00)15.00 (11.00–19.00)15.00 (10.00–20.00)0.848
GGT (U/L)19.50 (12.75–33.50)20.00 (16.00–29.50)20.00 (14.00–33.00)0.537
HOMA-IR2.23 (2.04–2.67)3.56 (3.05–4.53)2.88 (2.23–3.58)
HOMA-β121.91 (107.22–150.61)70.77 (50.95–89.29)103.33 (70.77–128.00)
ANGPTL5 (pg/ml)184.70±68.59321.21±79.30252.47±100.71
Data are presented as the mean±SD and median (interquartile range). Differences between groups were analyzed by the independent test, chi-square test, or Mann-Whitney test. MS – metabolic syndrome; WHR – waist-hip ratio; BMI – body mass index; SBP – systolic blood pressure; DBP – diastolic blood pressure; FPG – fasting plasma glucose; FINS – fasting insulin; HbA1c – glycated hemoglobin; TC – total cholesterol; TG – triglyceride; HDL-C – high-density lipoprotein cholesterol; LDL-C – low-density lipoprotein cholesterol; hs-CRP – high-sensitivity C-reactive protein; BUN – blood urea nitrogen; CREA – creatinine; URIC – uric acid; TBIL – total bilirubin; DBIL – direct bilirubin; IBIL – indirect bilirubin; AST – aspartate aminotransferase; ALT – alanine aminotransferase; GGT – glutamine transpeptidase; HOMA-IR – homeostasis model assessment of insulin resistance; HOMA-β – HOMA of β-cell function; ANGPTL5 – angiopoietinlike protein 5.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750