24 March 2021>: Clinical Research
Contribution of Interstitial Cells of Cajal to Gastrointestinal Stromal Tumor Risk
Qi Wang 1ABEG* , Zhen-peng Huang 2ACDEF** , Yu Zhu 3B , Fei Fu 1B , Lin Tian 1ABDG*DOI: 10.12659/MSM.929575
Med Sci Monit 2021; 27:e929575
Table 3 ICCs and CD117-positive grade and GISTs risk.
NIH criteria | CD117/c-kit (−) | CD117/c-kit (+) | CD117/c-kit (++) | CD117/c-kit (+++) |
---|---|---|---|---|
Very low risk | 2 (4.55%) | 22 (50.00%) | 11 (25.00%) | 9 (20.45%) |
Low risk | 2 (6.90%) | 14 (48.28%) | 6 (20.69%) | 7 (24.13%) |
Intermediate risk | 0 (0.00%) | 5 (31.25%) | 4 (25.00%) | 7 (43.75%) |
High risk | 3 (9.0%) | 6 (18.18%) | 8 (24.24%) | 16 (48.48%) |
# χ=9.6482, =0.0218. Most high-risk GIST cases were highly positive for ICCs and had high expression of CD117 (+++). Nearly half of the very low-risk and low-risk GIST cases had low levels of ICCs and CD117 (+) (χ=9.6482, =0.0218). |