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24 March 2021: Clinical Research

Contribution of Interstitial Cells of Cajal to Gastrointestinal Stromal Tumor Risk

Qi Wang 1ABEG* , Zhen-peng Huang 2ACDEF** , Yu Zhu 3B , Fei Fu 1B , Lin Tian 1ABDG*

DOI: 10.12659/MSM.929575

Med Sci Monit 2021; 27:e929575

Table 3 ICCs and CD117-positive grade and GISTs risk.

NIH criteriaCD117/c-kit (−)CD117/c-kit (+)CD117/c-kit (++)CD117/c-kit (+++)
Very low risk2 (4.55%)22 (50.00%)11 (25.00%)9 (20.45%)
Low risk2 (6.90%)14 (48.28%)6 (20.69%)7 (24.13%)
Intermediate risk0 (0.00%)5 (31.25%)4 (25.00%)7 (43.75%)
High risk3 (9.0%)6 (18.18%)8 (24.24%)16 (48.48%)
# χ=9.6482, =0.0218.
Most high-risk GIST cases were highly positive for ICCs and had high expression of CD117 (+++). Nearly half of the very low-risk and low-risk GIST cases had low levels of ICCs and CD117 (+) (χ=9.6482, =0.0218).

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750