25 February 2021>: Database Analysis
Combining Blood-Based Biomarkers to Predict Mortality of Sepsis at Arrival at the Emergency Department
Yinjing Xie 1CE* , Binbin Li 2BC* , Ying Lin 1BD , Fei Shi 2AG* , Weibu Chen 1AF* , Wenyuan Wu 1F , Wenjia Zhang 1B , Yun Fei 1D , Shiqing Zou 1D , Can Yao 2CDOI: 10.12659/MSM.929527
Med Sci Monit 2021; 27:e929527
Table 4 Prognostic value of clinical parameters.
Blood biomarkers | AUC | 95% CI | Cut off | Sensitivity | Specificity | P-value |
---|---|---|---|---|---|---|
hs-CRP | 0.417 | 0.280–0.553 | 436.34 | 0.043 | 0.985 | 0.235 |
PCT | 0.471 | 0.342–0.600 | 2.02 | 0.913 | 0.224 | 0.681 |
IL-6 | 0.675 | 0.534–0.816 | 2580.50 | 0.565 | 0.866 | 0.013* |
Lactate | 0.710 | 0.568–0.852 | 5.385 | 0.522 | 0.940 | 0.003* |
WBC | 0.497 | 0.354–0.640 | 16.54 | 0.348 | 0.761 | 0.967 |
NWR | 0.383 | 0.240–0.525 | 0.96 | 0.087 | 0.940 | 0.094 |
qSOFA | 0.512 | 0.373–0.650 | 2.50 | 0.217 | 0.806 | 0.868 |
IL-6+PCT | 0.753 | 0.639–0.868 | – | 0.91 | 0.48 | 0.000* |
IL-6+Lactate | 0.718 | 0.578–0.858 | – | 0.65 | 0.84 | 0.002* |
PCT+Lactate | 0.736 | 0.613–0.859 | – | 0.52 | 0.88 | 0.001* |
PCT+ NWR | 0.617 | 0.475–0.760 | – | 0.40 | 0.87 | 0.094 |
NWR+Lactate | 0.710 | 0.529–0.870 | – | 0.52 | 0.94 | 0.003* |
IL-6+NWR | 0.742 | 0.614–0.871 | – | 0.61 | 0.82 | 0.001* |
IL-6+PCT+Lactate | 0.780 | 0.662–0.898 | – | 0.65 | 0.84 | 0.000* |
NWR+PCT+Lactate | 0.807 | 0.706–0.908 | – | 0.74 | 0.75 | 0.000* |
NWR+IL-6+Lactate | 0.718 | 0.578–0.858 | – | 0.65 | 0.84 | 0.002* |
NWR+IL-6+PCT | 0.796 | 0.690–0.901 | – | 0.78 | 0.72 | 0.000* |
NWR+IL-6+PCT+Lactate | 0.823 | 0.723–0.924 | – | 0.65 | 0.91 | 0.000* |
* Indicates a significant value, AUC – area under the curve; CI – confidence interval; hs-CRP – high-sensitivity C-reactive protein; IL-6 – interleukin 6; NWR – neutrophil-to-WBC ratio; PCT – procalcitonin; WBC – white blood cell. |