25 February 2021: Database Analysis
Combining Blood-Based Biomarkers to Predict Mortality of Sepsis at Arrival at the Emergency Department
Yinjing Xie 1CE* , Binbin Li 2BC* , Ying Lin 1BD , Fei Shi 2AG* , Weibu Chen 1AF* , Wenyuan Wu 1F , Wenjia Zhang 1B , Yun Fei 1D , Shiqing Zou 1D , Can Yao 2CDOI: 10.12659/MSM.929527
Med Sci Monit 2021; 27:e929527
Table 1 Demographic characteristics.
| Characteristics | Survivor group (n=67) | Non-survivor group (n=23) | Total (n=90) | P value |
|---|---|---|---|---|
| Age, median (range) | 72 (26–97) | 77 (50–97) | 74 (26–97) | 0.127 |
| Sex, Male, n (%) | 44 (65.7) | 14 (60.9) | 58 (64.4) | 0.678 |
| BMI, mean (SD) | 25.7 (2.5) | 24.3 (2.1) | 25.1 (2.2) | 0.754 |
| MAP(mmHg), mean (SD) | 86.6 (16.6) | 83.1 (15.2) | 85.7 (16.3) | 0.380 |
| Comorbidities | ||||
| Hemiplegic stroke, n (%) | 14 (20.9) | 12 (52.2) | 26 (28.9) | 0.004* |
| Diabetes mellitus, n (%) | 24 (35.8) | 7 (30.4) | 31 (34.4) | 0.639 |
| Hypertension, n (%) | 31 (46.3) | 17 (73.9) | 48 (53.3) | 0.022* |
| Cardiovascular disease, n (%) | 15 (22.4) | 9 (39.1) | 24 (26.7) | 0.117 |
| Chronic renal failure, n (%) | 24 (35.8) | 10 (43.5) | 34 (37.8) | 0.513 |
| Chronic lung disease, n (%) | 11 (16.4) | 5 (21.7) | 16 (17.8) | 0.795 |
| Use of vasopressors, n (%) | 9 (13.4) | 5 (21.7) | 14 (15.6) | 0.618 |
| Use of mechanical ventilation, n (%) | 19 (30.2) | 8 (29.6) | 27 (30.0) | 0.960 |
| Pathogen | ||||
| Gram positive bacteria, n (%) | 4 (5.9) | 1 (4.3) | 5 (5.6) | 0.621 |
| Gram negative bacteria, n (%) | 12 (17.9) | 6 (26.1) | 18 (20.0) | 0.287 |
| Fungi, n (%) | 10 (14.9) | 4 (17.4) | 14 (15.6) | 0.436 |
| Site of primary infection | ||||
| Pneumonia, n (%) | 42 (62.7) | 19 (82.6) | 61 (67.8) | 0.078 |
| Urinary tract infection, n (%) | 26 (38.8) | 5 (21.7) | 31 (34.4) | 0.137 |
| Intra-abdominal infection, n (%) | 11 (16.4) | 3 (13.0) | 14 (15.6) | 0.959 |
| Soft tissue infection, n (%) | 3 (4.5) | 0 | 3 (3.3) | 0.720 |
| SOFA score, mean (SD) | 6.5 (3.7) | 9.7 (4.8) | 7.5 (4.3) | 0.001* |
| Duration of hospital | ||||
| ICU stay (day), mean (SD) | 5.9 (5.3) | 4.3 (3.3) | 5.5 (4.9) | 0.180 |
| Hospital stay (day), mean (SD) | 12.0 (9.2) | 10.4 (5.4) | 11.6 (8.4) | 0.316 |
| * Indicates a significant value, BMI – body mass index; ICU – Intensive Care Unit; MAP – mean arterial blood pressure; SD – standard deviation; SOFA – the Sequential Organ Failure Assessment. | ||||