18 April 2021: Animal Study
Left Ventricular Impaired Relaxation and Interstitial Myocarditis Identified in Sepsis-Associated Cardiac Dysfunction: Use of a Rodent Model
David J. Sturgess 1ABCDEFG* , Shannon Morrison 1BCDE , Brian Haluska 2BCD , Glenda C. Gobe 23BCDEG , Mark A. Jones 4ACDE , Sonia Volante 1BE , Bala Venkatesh 2ACDEGDOI: 10.12659/MSM.929512
Med Sci Monit 2021; 27:e929512
Table 1 Final assessment of function: LPS model.
| Variable | Control | Endotoxin | P-value |
|---|---|---|---|
| MAP (mmHg) | 124.29±20.16 | 81.86±31.67 | 0.020 |
| Heart rate (bpm) | 421.1±47 | 451.2±46.4 | 0.20 |
| LVIDs (mm) | 0.39±0.12 | 0.61±0.19 | 0.13 |
| LVIDd (mm) | 0.67±0.11 | 0.26±0.14 | 0.70 |
| FS (%) | 43.3±9.5 | 58.8±17.2 | 0.085 |
| VTI (cm) | 9±6 | 5.27±1.73 | 0.093 |
| Vpeak (m/s) | 4.17±0.74 | 1.35±1.73 | 0.17 |
| E (m/s) | 0.83±0.24 | 0.79±0.13 | 0.65 |
| e′ (m/s) | 0.09±0.02 | 0.06±0.02 | 0.008 |
| E/e′ | 8.91±1.51 | 11.54±3.17 | 0.19 |
| Analysis of covariance (ANCOVA) performed to compare groups at final time point with adjustment for baseline measurements. LV end-systolic (LVIDs) and end-diastolic (LVIDd) internal dimension; FS – fractional shortening; VTI – velocity time integral; Vpeak – outflow peak velocity; Peak early (E) diastolic transmitral velocity; Peak early (e′) diastolic septal mitral annulus velocity; E/e′ – ratio of E to e′. | |||