31 July 2021>: Clinical Research
Clinical Benefit of Therapeutic Drug Monitoring in Colorectal Cancer Patients Who Received Fluorouracil-Based Chemotherapy
Xingqin Zhou 1BCE , Yazhou Chang 2BD , Jing Qian 1BF , Chaoyan Shen 1DEF , Jie Han 1EF , Hongyu Zhao 1DF , Renan Chang 3AG*DOI: 10.12659/MSM.929474
Med Sci Monit 2021; 27:e929474
Table 2 Comparison of patient between the Study Group and the Historical Group.
Variable | Historical Group (n=153) | Study Group (n=54) | P value |
---|---|---|---|
Sex, n (%) | 0.307 | ||
Male | 86 (56.2) | 26 (48.1) | |
Female | 67 (43.8) | 28 (51.9) | |
Age (years) | 0.423 | ||
Median | 66 | 68 | |
Range | 51–90 | 55–87 | |
Weight (kg) | 0.204 | ||
Mean | 68.5 | 70.4 | |
SD | 17.2 | 15.6 | |
Height (cm) | 0.363 | ||
Mean | 166.7 | 168.0 | |
SD | 9.7 | 8.5 | |
Baseline BSA (m) | 0.427 | ||
Average | 1.82 | 1.84 | |
SD | 0.21 | 0.19 | |
Pretreatment ECOG status | 0.624 | ||
0 | 75 | 30 | |
1 | 45 | 18 | |
2 | 24 | 6 | |
Starting infusional 5-FU dose (mg/m) | 0.125 | ||
Average | 2453 | 2384 | |
SD | 182 | 164 | |
Protocol of chemotherapy, n | 0.835 | ||
FOLFOX4 | 39 (4) | 14 | |
mFOLFOX6 | 68 () | 26 | |
FOLFIRI | 46 () | 14 | |
Treatment cycles | 0.999 | ||
1 | 87 | 54 | |
2 | 85 | 54 | |
3 | 78 | 50 | |
4 | 70 | 47 | |
5 | 65 | 44 | |
6 | 62 | 40 | |
Total | 447 | 289 | |
Adverse events | * | ||
No toxicity or mild toxicity | 262 | 259 | |
Severe toxicity | 185 | 30 | |
Chemotherapy response | 0.032* | ||
CR+PR | 82 | 38 | |
SD+PD | 71 | 16 | |
* SD – standard deviation; FOLFOX – oxaliplatin, folinate, 5-FU; FOLFIRI – irinotecan, folinate, 5-FU. |