14 July 2021: Animal Study
Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol
Jian-Hong Wu 1ABCDEF* , Chun-Fang Lv 1ABDE* , Xu-Jun Guo 1CDEF* , Huan Zhang 2CF , Jinde Zhang 1BD , Yangfeng Xu 1BD , Jian Wang 1AEG** , Sheng-Yuan Liu 1ACEFG***DOI: 10.12659/MSM.929346
Med Sci Monit 2021; 27:e929346
Table 4 Effect of emodin on parameters of oxidative stress.
| Group | Control | HCD | SIM (10 mg/kg) | EH (100 mg/kg) | EM (30 mg/kg) | EL (10 mg/kg) |
|---|---|---|---|---|---|---|
| SOD-liver (U/mg protein) | 38.98±2.45 | 28.51±2.04### | 30.49±2.40### | 22.12±3.70,### | 22.84±5.48,### | 32.94±6.36,## |
| CAT-liver (U/mg protein) | 22.27±2.24 | 17.73±1.94## | 18.08±0.86# | 12.608±3.55,### | 14.76±3.63,### | 16.16±5.38## |
| MDA-liver (nmol/mg protein) | 2.14±0.35 | 3.07±0.23### | 2.37±0.25** | 2.22±0.73*** | 1.79±0.24*** | 1.85±0.34*** |
| SOD-serum (U/mL) | 163.37±4.43 | 135.41±4.92### | 135.55±7.52### | 113.26±12.58,### | 162.48±5.47*** | 168.16±4.39*** |
| CAT-serum (U/mL) | 5.39±1.42 | 3.02±0.81## | 3.82±1.93# | 3.37±0.92## | 4.49±1.21* | 5.13±1.63** |
| MDA-serum (nmol/mL) | 12.71±1.76 | 24.43±4.04### | 8.50±1.67,## | 16.36±2.94,## | 12.26±2.47*** | 7.67±0.98,### |
| The values represent the average of 6 to 8 separate experiments±standard deviation. HCD – high-cholesterol diet group; SIM – simvastatin group; EH – high-dose emodin group; EM – medium-dose emodin group; EL – low-dose emodin group; SOD-liver – superoxide dismutase activity in liver tissue; CAT-liver – catalase activity in liver tissue; MDA-liver – concentration of malondialdehyde in liver tissue; SOD-serum – superoxide dismutase activity in serum; CAT-serum – catalase activity in serum; MDA-serum – concentration of malondialdehyde in serum. # ## ### * ** *** | ||||||