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14 July 2021: Animal Study

Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol

Jian-Hong Wu 1ABCDEF* , Chun-Fang Lv 1ABDE* , Xu-Jun Guo 1CDEF* , Huan Zhang 2CF , Jinde Zhang 1BD , Yangfeng Xu 1BD , Jian Wang 1AEG** , Sheng-Yuan Liu 1ACEFG***

DOI: 10.12659/MSM.929346

Med Sci Monit 2021; 27:e929346

Table 3 The maximum relaxation (%) and pEC50 values of each group. Data are expressed as mean±standard deviation. Emax represents the maximal relaxation (%) with 10 μM of acetylcholine; the pEC50 (the negative logarithm of the concentration of acetylcholine giving 50% relaxation) values were obtained directly from individual log concentration-response curves; n represents the number of animals.

GroupEmax (%)pEC50 (M)n
HCD49.83±15.60## 6.55±0.31# 6
SIM (10 mg/kg)84.70±6.19** 7.03±0.21** 8
EH (100 mg/kg)71.26±19.146.67±0.367
EM (30 mg/kg)88.25±14.20** 6.87±0.206
EL (10 mg/kg)88.02±20.84** 7.03±0.33** 6
HCD – high-cholesterol diet group; SIM – simvastatin group; EH – high-dose emodin group; EM – medium-dose emodin group; EL – low-dose emodin group.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750