14 July 2021: Animal Study
Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol
Jian-Hong Wu 1ABCDEF* , Chun-Fang Lv 1ABDE* , Xu-Jun Guo 1CDEF* , Huan Zhang 2CF , Jinde Zhang 1BD , Yangfeng Xu 1BD , Jian Wang 1AEG** , Sheng-Yuan Liu 1ACEFG***DOI: 10.12659/MSM.929346
Med Sci Monit 2021; 27:e929346
Table 3 The maximum relaxation (%) and pEC50 values of each group. Data are expressed as mean±standard deviation. Emax represents the maximal relaxation (%) with 10 μM of acetylcholine; the pEC50 (the negative logarithm of the concentration of acetylcholine giving 50% relaxation) values were obtained directly from individual log concentration-response curves; n represents the number of animals.
| Group | Emax (%) | pEC50 (M) | n |
|---|---|---|---|
| Control | 88.91±21.14 | 6.89±0.13 | 6 |
| HCD | 49.83±15.60## | 6.55±0.31# | 6 |
| SIM (10 mg/kg) | 84.70±6.19** | 7.03±0.21** | 8 |
| EH (100 mg/kg) | 71.26±19.14 | 6.67±0.36 | 7 |
| EM (30 mg/kg) | 88.25±14.20** | 6.87±0.20 | 6 |
| EL (10 mg/kg) | 88.02±20.84** | 7.03±0.33** | 6 |
| HCD – high-cholesterol diet group; SIM – simvastatin group; EH – high-dose emodin group; EM – medium-dose emodin group; EL – low-dose emodin group. # ## ** | |||