14 July 2021: Animal Study
Low Dose of Emodin Inhibits Hypercholesterolemia in a Rat Model of High Cholesterol
Jian-Hong Wu 1ABCDEF* , Chun-Fang Lv 1ABDE* , Xu-Jun Guo 1CDEF* , Huan Zhang 2CF , Jinde Zhang 1BD , Yangfeng Xu 1BD , Jian Wang 1AEG** , Sheng-Yuan Liu 1ACEFG***DOI: 10.12659/MSM.929346
Med Sci Monit 2021; 27:e929346
Table 2 Serum lipid profiles of rats in each group.
| Group | Control | HCD | SIM (10 mg/kg) | EH (100 mg/kg) | EM (30 mg/kg) | EL (10 mg/kg) |
|---|---|---|---|---|---|---|
| Total-Cholesterol | 2.36±0.13 | 5.73±0.89### | 3.77±0.98,## | 4.42±0.87,### | 4.63±0.92,## | 4.53±0.56,### |
| Triglyceride | 0.70±0.04 | 0.73±0.09 | 0.68±0.08 | 0.71±0.19 | 0.54±0.10,# | 0.53±0.09,# |
| LDL-C | 0.35±0.13 | 1.00±0.09### | 0.77±0.25,### | 0.95±0.14### | 0.83±0.18### | 0.59±0.22,# |
| HDL-C | 0.63±0.14 | 1.34±0.15### | 1.41±0.15### | 1.34±0.35### | 1.40±0.17### | 1.43±0.31### |
| Atherogenic index | 2.21±0.30 | 3.54±0.66## | 2.38±0.47** | 2.64±0.68* | 2.77±0.85* | 2.59±0.23* |
| The values represent the average of 6 to 8 separate experiments standard deviation and expressed in mmol/L. HCD – high-cholesterol diet group; SIM – simvastatin group; EH – high-dose emodin group; EM – medium-dose emodin group; EL – low-dose emodin group; LDL-C – low-density lipoprotein cholesterol; HDL-C – high-density lipoprotein cholesterol. Atherogenic index=[(total-C)–(HDL-C)]/(HDL-C). # ## ### * ** *** | ||||||