Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan; Lu Gan; Di Jin; Xiaowei Wu; Luyang Cheng; Meiling Liu; Ying Fan; Jing Zhou; Hanlu Zhang; Yina Zhang; Ping Zhou

doi:10.12659/MSM.929170

20 April 2021: Clinical Research

Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

Jiaxin Guan ^1BCEF , Lu Gan ^1B , Di Jin ^1ACD , Xiaowei Wu ^1B , Luyang Cheng ^1C , Meiling Liu ^1C , Ying Fan ^1B , Jing Zhou ^2B , Hanlu Zhang ^1B , Yina Zhang ^1AFG* , Ping Zhou ^1FG*

DOI: 10.12659/MSM.929170

Med Sci Monit 2021; 27:e929170

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Table 2 Differential expression of circRNAs on RNA-seq.

CircRNA	Regulation	Chromosome	Fold change	P value
hsa_circ_0021739	Down	Chr6	−8.51
hsa_circ_0019693	Down	Chr5	−4.29	0.001
hsa_circ_0013121	Up	Chr20	4.08	0.003
hsa_circ_0002332	Up	Chr11	3.69	0.008

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Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts

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