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14 February 2021: Database Analysis

Identification of Potential Biomarkers Associated with Prognosis in Gastric Cancer via Bioinformatics Analysis

Dong Li 1ABCDEF* , Yi Yin 2ACEG* , Muqun He 2BDF , Jianfeng Wang 2BDF

DOI: 10.12659/MSM.929104

Med Sci Monit 2021; 27:e929104

Table 2 Gene Ontology (GO) term enrichment analysis of differentially expressed genes (DEGs) in gastric cancer.

ExpressionCategoryTermCount%P-valueFDR
Up-regulatedGOTERM_BP_DIRECTGO: 0030199~collagen fibril organization411.496.43E-060.007663
GOTERM_BP_DIRECTGO: 0035987~endodermal cell differentiation38.624.66E-040.553934
GOTERM_BP_DIRECTGO: 0016525~negative regulation of angiogenesis38.620.0013841.636565
GOTERM_BP_DIRECTGO: 0032964~collagen biosynthetic process25.750.0051856.005438
GOTERM_BP_DIRECTGO: 0043589~skin morphogenesis25.750.00905710.272816
GOTERM_BP_DIRECTGO: 0070208~protein heterotrimerization25.750.01034511.652002
GOTERM_CC_DIRECTGO: 0005581~collagen trimer514.372.69E-072.44E-04
GOTERM_CC_DIRECTGO: 0005615~extracellular space1028.744.16E-073.78E-04
GOTERM_CC_DIRECTGO: 0005578~proteinaceous extracellular matrix411.490.0013081.182888
GOTERM_CC_DIRECTGO: 0005584~collagen type I trimer25.750.0027282.453896
GOTERM_CC_DIRECTGO: 0005923~bicellular tight junction38.620.0041483.709096
GOTERM_CC_DIRECTGO: 0016327~apicolateral plasma membrane25.750.01626413.853770
GOTERM_MF_DIRECTGO: 0005201~extracellular matrix structural constituent38.620.0010100.806984
GOTERM_MF_DIRECTGO: 0005198~structural molecule activity38.620.0122119.385704
Down-regulatedGOTERM_BP_DIRECTGO: 0007586~digestion118.701.33E-121.92E-09
GOTERM_BP_DIRECTGO: 0006081~cellular aldehyde metabolic process43.162.46E-050.035612
GOTERM_BP_DIRECTGO: 0001696~gastric acid secretion32.374.30E-040.619734
GOTERM_BP_DIRECTGO: 0010107~potassium ion import43.164.57E-040.659491
GOTERM_BP_DIRECTGO: 0006805~xenobiotic metabolic process53.958.48E-041.219547
GOTERM_BP_DIRECTGO: 0055114~oxidation-reduction process118.700.0013581.947012
GOTERM_CC_DIRECTGO: 0005615~extracellular space2620.561.19E-081.32E-05
GOTERM_CC_DIRECTGO: 0070062~extracellular exosome3023.731.24E-040.137838
GOTERM_CC_DIRECTGO: 0016323~basolateral plasma membrane75.543.39E-040.375425
GOTERM_CC_DIRECTGO: 0005887~integral component of plasma membrane1511.860.01347813.981885
GOTERM_CC_DIRECTGO: 0016324~apical plasma membrane64.750.01738817.691052
GOTERM_CC_DIRECTGO: 0005576~extracellular region1612.650.01754417.836177
GOTERM_MF_DIRECTGO: 0005242~inward rectifier potassium channel activity32.370.0040855.024893
GOTERM_MF_DIRECTGO: 0018479~benzaldehyde dehydrogenase (NAD+) activity21.580.00957411.410763
GOTERM_MF_DIRECTGO: 0008900~hydrogen: potassium-exchanging ATPase activity21.580.01432716.618617
GOTERM_MF_DIRECTGO: 0042802~identical protein binding97.120.02700229.160325
GOTERM_MF_DIRECTGO: 0005254~chloride channel activity32.370.02770129.799387
GOTERM_MF_DIRECTGO: 0001758~retinal dehydrogenase activity21.580.03311434.565617

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750