14 February 2021>: Database Analysis
Identification of Potential Biomarkers Associated with Prognosis in Gastric Cancer via Bioinformatics Analysis
Dong Li 1ABCDEF* , Yi Yin 2ACEG* , Muqun He 2BDF , Jianfeng Wang 2BDFDOI: 10.12659/MSM.929104
Med Sci Monit 2021; 27:e929104
Table 2 Gene Ontology (GO) term enrichment analysis of differentially expressed genes (DEGs) in gastric cancer.
Expression | Category | Term | Count | % | P-value | FDR |
---|---|---|---|---|---|---|
Up-regulated | GOTERM_BP_DIRECT | GO: 0030199~collagen fibril organization | 4 | 11.49 | 6.43E-06 | 0.007663 |
GOTERM_BP_DIRECT | GO: 0035987~endodermal cell differentiation | 3 | 8.62 | 4.66E-04 | 0.553934 | |
GOTERM_BP_DIRECT | GO: 0016525~negative regulation of angiogenesis | 3 | 8.62 | 0.001384 | 1.636565 | |
GOTERM_BP_DIRECT | GO: 0032964~collagen biosynthetic process | 2 | 5.75 | 0.005185 | 6.005438 | |
GOTERM_BP_DIRECT | GO: 0043589~skin morphogenesis | 2 | 5.75 | 0.009057 | 10.272816 | |
GOTERM_BP_DIRECT | GO: 0070208~protein heterotrimerization | 2 | 5.75 | 0.010345 | 11.652002 | |
GOTERM_CC_DIRECT | GO: 0005581~collagen trimer | 5 | 14.37 | 2.69E-07 | 2.44E-04 | |
GOTERM_CC_DIRECT | GO: 0005615~extracellular space | 10 | 28.74 | 4.16E-07 | 3.78E-04 | |
GOTERM_CC_DIRECT | GO: 0005578~proteinaceous extracellular matrix | 4 | 11.49 | 0.001308 | 1.182888 | |
GOTERM_CC_DIRECT | GO: 0005584~collagen type I trimer | 2 | 5.75 | 0.002728 | 2.453896 | |
GOTERM_CC_DIRECT | GO: 0005923~bicellular tight junction | 3 | 8.62 | 0.004148 | 3.709096 | |
GOTERM_CC_DIRECT | GO: 0016327~apicolateral plasma membrane | 2 | 5.75 | 0.016264 | 13.853770 | |
GOTERM_MF_DIRECT | GO: 0005201~extracellular matrix structural constituent | 3 | 8.62 | 0.001010 | 0.806984 | |
GOTERM_MF_DIRECT | GO: 0005198~structural molecule activity | 3 | 8.62 | 0.012211 | 9.385704 | |
Down-regulated | GOTERM_BP_DIRECT | GO: 0007586~digestion | 11 | 8.70 | 1.33E-12 | 1.92E-09 |
GOTERM_BP_DIRECT | GO: 0006081~cellular aldehyde metabolic process | 4 | 3.16 | 2.46E-05 | 0.035612 | |
GOTERM_BP_DIRECT | GO: 0001696~gastric acid secretion | 3 | 2.37 | 4.30E-04 | 0.619734 | |
GOTERM_BP_DIRECT | GO: 0010107~potassium ion import | 4 | 3.16 | 4.57E-04 | 0.659491 | |
GOTERM_BP_DIRECT | GO: 0006805~xenobiotic metabolic process | 5 | 3.95 | 8.48E-04 | 1.219547 | |
GOTERM_BP_DIRECT | GO: 0055114~oxidation-reduction process | 11 | 8.70 | 0.001358 | 1.947012 | |
GOTERM_CC_DIRECT | GO: 0005615~extracellular space | 26 | 20.56 | 1.19E-08 | 1.32E-05 | |
GOTERM_CC_DIRECT | GO: 0070062~extracellular exosome | 30 | 23.73 | 1.24E-04 | 0.137838 | |
GOTERM_CC_DIRECT | GO: 0016323~basolateral plasma membrane | 7 | 5.54 | 3.39E-04 | 0.375425 | |
GOTERM_CC_DIRECT | GO: 0005887~integral component of plasma membrane | 15 | 11.86 | 0.013478 | 13.981885 | |
GOTERM_CC_DIRECT | GO: 0016324~apical plasma membrane | 6 | 4.75 | 0.017388 | 17.691052 | |
GOTERM_CC_DIRECT | GO: 0005576~extracellular region | 16 | 12.65 | 0.017544 | 17.836177 | |
GOTERM_MF_DIRECT | GO: 0005242~inward rectifier potassium channel activity | 3 | 2.37 | 0.004085 | 5.024893 | |
GOTERM_MF_DIRECT | GO: 0018479~benzaldehyde dehydrogenase (NAD+) activity | 2 | 1.58 | 0.009574 | 11.410763 | |
GOTERM_MF_DIRECT | GO: 0008900~hydrogen: potassium-exchanging ATPase activity | 2 | 1.58 | 0.014327 | 16.618617 | |
GOTERM_MF_DIRECT | GO: 0042802~identical protein binding | 9 | 7.12 | 0.027002 | 29.160325 | |
GOTERM_MF_DIRECT | GO: 0005254~chloride channel activity | 3 | 2.37 | 0.027701 | 29.799387 | |
GOTERM_MF_DIRECT | GO: 0001758~retinal dehydrogenase activity | 2 | 1.58 | 0.033114 | 34.565617 |