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04 March 2021: Database Analysis

Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma

Xuemiao Zhao 1ABEF , Wei Weng 2ACDE , Miao Jin 3CD , Sunjian Li 4AB , Qingwei Chen 5EF , Bingrong Li 2BC , Zhou Zhou 6BC , Chuanqiang Lan 2BE , Yunjun Yang 1AEF*

DOI: 10.12659/MSM.929023

Med Sci Monit 2021; 27:e929023

Table 3 Functional roles of 16 hub genes with degree ≥10.

Gene symbolFull nameFunction
UBE2TUbiquitin-conjugating enzyme E2 TCatalyzes the covalent attachment of ubiquitin to protein substrates
HABP2Hyaluronan binding protein 2Encodes a member of the peptidase S1 family of serine proteases
MT1MMetallothionein 1MEncodes a member of the metallothionein superfamily, type 1 family
CFPComplement factor properdinEncodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system
ENO3Enolase 3Encodes 1 of the 3 enolase isoenzymes found in vertebrates
CYP2C18Cytochrome P450 family 2 subfamily C member 18Encodes a member of the cytochrome P450 superfamily of enzymes.
CCL2C-C motif chemokine ligand 21 of several cytokine genes clustered on the q-arm of chromosome 17
FBLN5Fibulin 5Protein encoded is a secreted, extracellular matrix protein containing an Arg-Gly-Asp motif and calcium-binding EGF-like domains
KMOKynurenine 3-monooxygenaseEncodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine
ACMSDAminocarboxymuconate semialdehyde decarboxylaseConverts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde to alpha-aminomuconate semialdehyde
PTGS2Prostaglandin-endoperoxide synthase 2Encodes an enzyme that is a member of the prostaglandin G/H synthase family
CLEC1BC-type lectin domain family 1, member bCLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750