Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

04 March 2021: Database Analysis

Identification of Biomarkers Based on Bioinformatics Analysis: The Expression of Ubiquitin-Conjugating Enzyme E2T (UBE2T) in the Carcinogenesis and Progression of Hepatocellular Carcinoma

Xuemiao Zhao 1ABEF , Wei Weng 2ACDE , Miao Jin 3CD , Sunjian Li 4AB , Qingwei Chen 5EF , Bingrong Li 2BC , Zhou Zhou 6BC , Chuanqiang Lan 2BE , Yunjun Yang 1AEF*

DOI: 10.12659/MSM.929023

Med Sci Monit 2021; 27:e929023

Table 1 GO and KEGG pathway enrichment analysis of DEGs in HCC samples.

CategoryTermDescriptionCountFDR
GOTERM_BP_DIRECTGO: 0019373Epoxygenase P450 pathway108.46E-10
GOTERM_BP_DIRECTGO: 0055114Oxidation-reduction process301.60E-06
GOTERM_BP_DIRECTGO: 0006956Complement activation115.79E-05
GOTERM_BP_DIRECTGO: 0006805Xenobiotic metabolic process101.74E-04
GOTERM_BP_DIRECTGO: 0071356Cellular response to tumor necrosis factor100.002280078
GOTERM_BP_DIRECTGO: 0006508Proteolysis200.004661937
GOTERM_CC_DIRECTGO: 0005576Extracellular region632.51E-13
GOTERM_CC_DIRECTGO: 0031090Organelle membrane162.80E-11
GOTERM_CC_DIRECTGO: 0070062Extracellular exosome793.65E-10
GOTERM_CC_DIRECTGO: 0005615Extracellular space481.08E-08
GOTERM_CC_DIRECTGO: 0072562Blood microparticle121.30E-04
GOTERM_MF_DIRECTGO: 0020037Heme binding198.03E-11
GOTERM_MF_DIRECTGO: 0016705Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen148.03E-11
GOTERM_MF_DIRECTGO: 0004497Monooxygenase activity131.55E-09
GOTERM_MF_DIRECTGO: 0005506Iron ion binding181.94E-09
GOTERM_MF_DIRECTGO: 0019825Oxygen binding113.24E-08
GOTERM_MF_DIRECTGO: 0004252Serine-type endopeptidase activity171.73E-05
GOTERM_MF_DIRECTGO: 0003824Catalytic activity110.008200616
KEGG_PATHWAYhsa01100Metabolic pathways585.92E-08
KEGG_PATHWAYhsa04610Complement and coagulation cascades117.69E-05
KEGG_PATHWAYhsa05204Chemical carcinogenesis112.30E-04
KEGG_PATHWAYhsa01200Carbon metabolism127.12E-04
KEGG_PATHWAYhsa01130Biosynthesis of antibiotics140.007712682
GOTERM_BP_DIRECTGO: 0007067Mitotic nuclear division109.83E-06
GOTERM_BP_DIRECTGO: 0051301Cell division119.83E-06
GOTERM_CC_DIRECTGO: 0005654Nucleoplasm221.84E-04
GOTERM_CC_DIRECTGO: 0005634Nucleus307.93E-04
GOTERM_CC_DIRECTGO: 0005829Cytosol210.005534764
GO – Gene Ontology; KEGG – Kyoto Encyclopedia of Genes and Genomes; DEGs – differentially expressed genes; HCC – hepatocellular carcinoma; FDR – false discovery rate.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750