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03 February 2021: Clinical Research

U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study

Hao You 1ABCE* , Kegong Chen 2BCE* , Pengfei Han 3C , ChaoFu Yue 4B , Xia Zhao 5ADEG*

DOI: 10.12659/MSM.928937

Med Sci Monit 2021; 27:e928937

Supplementary Table 4 Stratification analysis by BMI.

Uric acid, mg/dlBMI <30 (n=8,396)p ValueBMI ≥30 (n=7,150)p Value
HR (95% CI)HR (95% CI)
All-cause mortality
 ≤3.51.41 (1.02–1.94)0.0352.05 (1.29–3.26)0.003
 3.5–5.01.08 (0.94–1.24)0.2801.22 (0.94–1.58)0.129
 5.0–6.01 (ref.)1 (ref.)
 6.0–7.51.13 (0.96–1.33)0.1521.01 (0.81–1.25)0.948
 >7.51.43 (1.20–1.70)0.0001.23 (0.93–1.63)0.142
CVD mortality*1 (ref.)1 (ref.)
 ≤3.52.42 (1.25–4.66)0.0091.37 (0.30–6.32)0.682
 3.5–5.01.29 (0.86–1.95)0.2131.46 (0.79–2.68)0.220
 5.0–6.01 (ref.)1 (ref.)
 6.0–7.51.34 (0.92–1.94)0.1230.94 (0.62–1.43)0.768
 >7.51.24 (0.75–2.05)0.3971.51 (0.80–2.84)0.197
Heart-related mortality1 (ref.)1 (ref.)
 ≤3.51.67 (0.90–3.09)0.1051.57 (0.46–5.35)0.467
 3.5–5.01.22 (0.85–1.73)0.2751.43 (0.77–2.68)0.259
 5.0–6.01 (ref.)1 (ref.)
 6.0–7.51.32 (0.94–1.86)0.1120.97 (0.66–1.44)0.896
 >7.51.17 (0.74–1.84)0.4941.74 (1.02–2.99)0.044
Stroke mortality*1 (ref.)1 (ref.)
 ≤3.54.24 (1.46–12.34)0.0095.74 (0.60–54.82)0.126
 3.5–5.01.28 (0.62–2.63)0.4980.77 (0.27–2.22)0.620
 5.0–6.01 (ref.)1 (ref.)
 6.0–7.51.17 (0.51–2.67)0.7061.07 (0.38–2.95)0.901
 >7.51.71 (0.58–5.06)0.3260.99 (0.25–3.84)0.985
Cancer mortality1 (ref.)1 (ref.)
 ≤3.51.48 (0.71–3.12)0.2952.88 (1.41–5.86)0.004
 3.5–5.01.06 (0.75–1.49)0.7361.06 (0.66–1.70)0.810
 5.0–6.01 (ref.)1 (ref.)
 6.0–7.51.09 (0.79–1.50)0.6111.10 (0.64–1.89)0.721
 >7.51.45 (0.96–2.20)0.0761.01 (0.57–1.78)0.972

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750