U-Shaped Relationship Between Cardiovascular Mortality and Serum Uric Acid May Be Attributed to Stroke- and Heart-Specific Mortality, Respectively, Among Hypertensive Patients: A Nationally Representative Cohort Study

03 February 2021: Clinical Research

Hao You ^1ABCE* , Kegong Chen ^2BCE* , Pengfei Han ^3C , ChaoFu Yue ^4B , Xia Zhao ^5ADEG*

DOI: 10.12659/MSM.928937

Med Sci Monit 2021; 27:e928937

Supplementary Table 1 Stratification analysis of the association between uric acid and mortality by sex.

Uric acid, mg/dl	Female (n=7,850)	p Value	Male (n=7,309)	p Value
Uric acid, mg/dl	HR (95% CI)	p Value	HR (95% CI)	p Value
All-cause mortality
≤3.5	1.33 (0.93–1.91)	0.118	2.46 (1.57–3.86)	0.000
3.5–5.0	1.11 (0.90–1.35)	0.322	1.17 (0.96–1.42)	0.115
5.0–6.0	1 (ref.)		1 (ref.)
6.0–7.5	1.27 (1.04–1.56)	0.022	0.97 (0.81–1.16)	0.736
>7.5	1.48 (1.18–1.85)	0.001	1.29 (1.04–1.60)	0.019
CVD mortality^*
≤3.5	2.28 (1.14–4.55)	0.020	1.52 (0.45–5.14)	0.491
3.5–5.0	1.23 (0.75–2.03)	0.407	1.41 (0.92–2.17)	0.112
5.0–6.0	1 (ref.)		1 (ref.)
6.0–7.5	1.48 (0.89–2.44)	0.126	1.04 (0.70–1.54)	0.849
>7.5	1.56 (0.90–2.68)	0.108	1.49 (0.92–2.42)	0.105
Heart-related mortality
≤3.5	1.34 (0.66–2.73)	0.419	1.16 (0.27–5.08)	0.840
3.5–5.0	1.02 (0.62–1.67)	0.937	1.39 (0.92–2.09)	0.114
5.0–6.0	1 (ref.)		1 (ref.)
6.0–7.5	1.28 (0.82–2.02)	0.278	1.10 (0.77–1.57)	0.611
>7.5	1.47 (0.86–2.52)	0.160	1.55 (1.04–2.31)	0.032
Stroke mortality^*
≤3.5	2.28 (1.16–4.50)	0.018	1.50 (0.13–17.07)	0.741
3.5–5.0	1.21 (0.73–2.01)	0.460	1.47 (0.58–3.76)	0.411
5.0–6.0	1 (ref.)		1 (ref.)
6.0–7.5	1.39 (0.83–2.30)	0.203	1.23 (0.47–3.22)	0.665
>7.5	1.36 (0.79–2.34)	0.256	1.26 (0.35–4.60)	0.719
^* Estimated in NHANES 1999–2006. Hazard ratio (95% confidence interval) was estimated via weighted cox regression analysis after adjustment for age (years, continuous), race/ethnicity (non-Hispanic white, black, Hispanic-Mexican, or other), poverty to income ratio (