Functional Analysis of Estrogen Receptor 1 in Diabetic Wound Healing: A Knockdown Cell-Based and Bioinformatic Study

18 December 2020: Database Analysis

Sha Qi ^ABC , Qiong Han ^BC , Danmou Xing ^D , Long Qian ^CE , Xiang Yu ^E , Dong Ren ^F , Huan Wang ^E , Quan Chen ^ABFG*

DOI: 10.12659/MSM.928788

Med Sci Monit 2020; 26:e928788

Table 6 Functional and pathway enrichment analyses of the genes in the protein–protein (PPI) network.

Term	Name	Count	P-value

GO: 0045597	Positive regulation of cell differentiation	66	1.7E-7
GO: 0072358	Cardiovascular system development	68	2.4E-6
GO: 0072359	Circulatory system development	68	2.4E-6

GO: 0005654	Nucleoplasm	153	3.1E-3
GO: 0005578	Proteinaceous extracellular matrix	27	4.6E-3
GO: 0097517	Contractile actin filament bundle	8	6.7E-3

GO: 0098772	Molecular function regulator	84	6.7E-5
GO: 0008134	Transcription factor binding	39	1.2E-4
GO: 0005539	Glycosaminoglycan binding	20	5.2E-4

hsa: 05205	Proteoglycans in cancer pathway	17	4.8E-3
hsa: 05200	Pathways in cancer	27	5.4E-3
hsa: 04390	Hippo signaling pathway	14	5.8E-3