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07 May 2021: Clinical Research

Real-World Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors (PCSK9i) in Heterozygous Familial Hypercholesterolemia Patients Referred for Lipoprotein Apheresis

Anthony Matta 123ABCDEF , Vanina Bongard 12ABCDEF , Frédéric Bouisset 12ABCDEF , Dorota Taraszkiewicz 12ABCDEF , Jean-Pierre Rabès 4BDEF , Jean Ferrières 12ABCDEFG*

DOI: 10.12659/MSM.928784

Med Sci Monit 2021; 27:e928784

Table 2 Analysis of variance (ANOVA) comparing the reduction in mean low-density lipoprotein cholesterol between the 3 groups after adding PCSK9i.

Mean variation in LDL-c (mg/dl±SD)Compared to95% CIP value
PCSK9i125±60PCSK9i+statin(−0.85; −0.15)0.002
PCSK9i+ezetimibe(−0.28; 0.72)0.86
PCSK9i+ezetimibe103±89PCSK9i(−0.72; 0.28)0.86
PCSK9i+statin(−1.28; −0.17)0.006
PCSK9i+statin and ezetimibe175±72PCSK9i(0.15; 0.85)0.002
PCSK9i+ezetimibe(0.17; 1.28)0.006
CI – confidence interval; HDL-c – high-density lipoprotein cholesterol; LDL-c – low-density lipoprotein cholesterol; PCSK9i – proprotein convertase subtilisin/kexin type 9 inhibitors.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750