23 January 2021: Database Analysis
Correlation Between High Expression of and Improved Overall Survival in Ovarian Cancer Patients
Hui Shang 1FG , Lingyun Shi 2BC , Xuena Jiang 3CF , Peng Zhou 4CD , Yongqing Wei 1AB*DOI: 10.12659/MSM.928763
Med Sci Monit 2021; 27:e928763
Table 1 Gene Ontology (GO) enrichment of FOXA2 and relevant genes.
| Description | Count | Q value | Gene ratio |
|---|---|---|---|
| Endocrine system development | 24 | 1.75E-35 | 0.2 |
| Positive regulation of transcription, DNA-templated | 42 | 1.75E-35 | 0.029268293 |
| Positive regulation of macromolecule biosynthetic process | 44 | 1.75E-35 | 0.025028441 |
| Positive regulation of transcription by RNA polymerase II | 39 | 2.23E-35 | 0.035326087 |
| Positive regulation of gene expression | 44 | 2.64E-35 | 0.024096386 |
| Positive regulation of cellular biosynthetic process | 44 | 3.02E-35 | 0.02383532 |
| Positive regulation of RNA metabolic process | 42 | 1.32E-34 | 0.026315789 |
| Regulation of transcription by RNA polymerase II | 45 | 1.64E-30 | 0.017090771 |
| Regionalization | 25 | 1.22E-28 | 0.079872204 |
| Pancreas development | 18 | 6.81E-28 | 0.25 |
| Nucleus | 43 | 1.41E-10 | 0.006239 |
| Intracellular membrane-bounded organelle | 49 | 8.56E-10 | 0.004727 |
| Transcription factor complex | 12 | 2.99E-09 | 0.03681 |
| Nucleoplasm | 29 | 1.72E-08 | 0.008416 |
| Intracellular organelle lumen | 35 | 1.72E-08 | 0.00678 |
| Nuclear lumen | 30 | 6.12E-08 | 0.007444 |
| Nuclear transcription factor complex | 7 | 4.32E-06 | 0.042169 |
| RNA polymerase II transcription factor complex | 5 | 0.00041 | 0.035971 |
| beta-catenin-TCF7L2 complex | 2 | 0.00071 | 0.666667 |
| Nuclear chromatin | 6 | 0.0023 | 0.018018 |
| Transcription regulatory region sequence-specific DNA binding | 34 | 4.06E-34 | 0.047887 |
| Sequence-specific DNA binding | 37 | 7.06E-34 | 0.035339 |
| Transcription regulatory region DNA binding | 35 | 7.06E-34 | 0.04222 |
| RNA polymerase II regulatory region sequence-specific DNA binding | 31 | 3.21E-31 | 0.047913 |
| DNA-binding transcription factor activity | 39 | 2.38E-29 | 0.022298 |
| DNA-binding transcription factor activity, RNA polymerase II-specific | 38 | 5.07E-29 | 0.023299 |
| DNA-binding transcription activator activity, RNA polymerase II-specific | 24 | 2.17E-25 | 0.058824 |
| Proximal promoter sequence-specific DNA binding | 24 | 5.92E-24 | 0.050526 |
| RNA polymerase II proximal promoter sequence-specific DNA binding | 23 | 7.84E-23 | 0.050328 |
| DNA binding | 38 | 8.70E-23 | 0.015466 |