19 February 2021: Clinical Research
Assessment of the Multiple Rapid Swallows Test for Gauging Esophageal Reflux Burden in Patients with Refractory Gastroesophageal Reflux Disease
Jing Chen BCE , Baona Guo BF , Chuxuan Bin D , Chuan Zhang G** , Yutao Zhan A**DOI: 10.12659/MSM.928554
Med Sci Monit 2021; 27:e928554
Table 3 High-resolution manometry and 24-h impedance-pH monitoring parameters of Phenotype 4.
| Normal MRS | Abnormal MRS | p Value | |
|---|---|---|---|
| CC ver3.0 (n) | |||
| IEM | 17 | 24 | |
| Fragmental peristalsis | 0 | 0 | |
| Normal esophageal motility | 22 | 28 | |
| EGJ morphology (type I/II/III) | 22/11/6 | 30/16/6 | |
| HRM ParametersMean±SD/Median (IQR) | |||
| SS DCI (mmHg·s·cm) | 507.00 (259.00, 921.00) | 541.00 (309.25, 992.50) | 0.566 |
| MRS DCI (mmHg·s·cm) | 730.00 (268.00, 1136.00) | 239.50 (69.50, 540.75) | |
| CFV (cm/s) | 4.60 (3.70, 5.20) | 4.60 (3.72, 5.60) | 0.647 |
| Break (cm) | 2.40 (1.10, 4.20) | 1.90 (1.13, 3.60) | 0.665 |
| DL (s) | 6.70 (6.20, 7.30) | 6.85 (6.00, 7.50) | 0.832 |
| IRP4 (mmHg) | 1.00 (−1.00, 3.00) | 2.00 (0.00, 5.00) | 0.106 |
| MRS IRP4 (mmHg) | 1.00 (−1.00, 4.00) | 1.00 (−1.00, 5.00) | 0.803 |
| LESP (mmHg) | 5.00 (1.00, 9.00) | 5.50 (1.25, 11.75) | 0.635 |
| Length of LES (cm) | 2.94±0.46 | 2.88±0.40 | 0.502 |
| DeMeester score | 3.20 (0.77, 6.98) | 2.70 (0.55, 7.63) | 0.642 |
| AET (%) | 0.80 (0.10, 2.00) | 0.55 (0.10, 1.78) | 0.459 |
| BET (%) | 0.50 (0.20, 0.90) | 0.50 (0.20, 0.80) | 0.990 |
| BCT (s) | 7.00 (6.00, 10.00) | 6.00 (5.00, 9.00) | 0.087 |
| Total reflux events (n) | 13.30 (4.00, 18.60) | 8.50 (2.10, 18.18) | 0.316 |
| Long-term acid reflux episodes (s) | 2.90 (1.10, 6.00) | 2.50 (0.50, 6.60) | 0.907 |
| Proximal extent (n) | 6.30 (2.10, 18.60) | 6.80 (2.10, 26.55) | 0.490 |
| Acid-Liquid episodes (n) | 0.00 (0.00, 1.00) | 0.00 (0.00, 1.00) | 0.855 |
| Acid-Mixed episodes (n) | 1.00 (0.00, 2.00) | 1.00 (0.00, 2.00) | 0.534 |
| Acid-Gas episodes (n) | 2.00 (1.00, 6.00) | 1.00 (0.00, 2.00) | 0.004 |
| Weakly acid-Liquid episodes (n) | 5.00 (1.00, 9.00) | 4.00 (2.00, 9.00) | 0.901 |
| Weakly acid-Mixed episodes (n) | 15.00 (4.00, 32.00) | 13.50 (4.25, 28.00) | 0.647 |
| Weakly acid-Gas episodes (n) | 46.00 (29.00, 70.00) | 25.50 (15.25, 46.50) | 0.001 |
| Nonacid-Liquid episodes (n) | 1.00 (0.00, 3.00) | 3.00 (0.00, 13.25) | 0.024 |
| Nonacid-Mixed episodes (n) | 5.00 (1.00, 14.00) | 4.00 (1.00, 16.75) | 0.872 |
| Nonacid-Gas episodes (n) | 26.00 (15.00, 37.00) | 20.00 (12.50, 33.75) | 0.480 |
| MNBI (ohms) | 2596.95±614.17 | 2485.38±621.66 | 0.397 |
| Acid reflux episodes (n) | 1.10 (0, 2.20) | 1.00 (0, 2.88) | 0.960 |
| Weakly acidic reflux episodes (n) | 18.20 (7.50, 35.90) | 14.85 (4.43, 30.85) | 0.218 |
| Nonacid reflux episodes (n) | 7.30 (1.20, 15.00) | 5.95 (1.03.23.58) | 0.936 |
| Liquid reflux episodes (n) | 4.40 (2.10, 8.30) | 6.75 (2.20, 13.35) | 0.212 |
| Mixed reflux episodes (n) | 25.40 (7.60, 45.80) | 17.50 (8.28, 36.00) | 0.303 |
| Gas reflux episodes (n) | 69.00 (48.50, 102.50) | 45.30 (29.20, 68.18) | 0.001 |
| Recumbent | |||
| Acid reflux episodes (n) | 0.00 (0, 1.10) | 0.00 (0.00, 0.00) | 0.392 |
| Weakly acidic reflux episodes (n) | 4.20 (1.10, 10.50) | 4.35 (1.33, 12.15) | 0.377 |
| Nonacid reflux episodes (n) | 0.00 (0, 2.20) | 1.65 (0, 7.25) | 0.004 |
| Liquid reflux episodes (n) | 2.20 (1.00, 5.50) | 2.65 (1.10, 8.38) | 0.396 |
| Mixed reflux episodes (n) | 2.20 (1.00, 8.30) | 3.50 (1.10, 9.78) | 0.261 |
| Gas reflux episodes (n) | 10.50 (4.10, 15.20) | 7.45 (3.13, 17.45) | 0.742 |
| Data are shown as the mean±SD or median (IQR). CC – Chicago Classification; IEM – ineffective esophageal motility; N – normal; SS – single swallow; MRS – multiple rapid swallows; CFV – contractile front velocity; DCI – distal contractile integral; DL – distal latency; IRP – integrated relaxation pressure; LESP – lower esophageal sphincter pressure; MNBI – mean nocturnal baseline impedance; AET – acid exposure percent time; BET – bolus exposure percent time; BCT – bolus clearance time. | |||