19 February 2021>: Clinical Research
Assessment of the Multiple Rapid Swallows Test for Gauging Esophageal Reflux Burden in Patients with Refractory Gastroesophageal Reflux Disease
Jing Chen BCE , Baona Guo BF , Chuxuan Bin D , Chuan Zhang G** , Yutao Zhan A**DOI: 10.12659/MSM.928554
Med Sci Monit 2021; 27:e928554
Table 2 Characteristics of the participants (N=151).
Phenotype 1 | Phenotype 2 | Phenotype 3 | Phenotype 4 | p Value | |
---|---|---|---|---|---|
n=18 | n=24 | n=18 | n=91 | ||
Age (years) | 57.28±16.24 | 52.42±14.41 | 58.17±12.31 | 53.84±12.63 | 0.403 |
Gender (M/F) | 9/9 | 10/14 | 10/8 | 43/48 | 0.840 |
Height (m) | 1.64±0.11 | 1.65±0.08 | 1.64±0.09 | 1.65±0.09 | 0.959 |
Weight (kg) | 68.67±11.97 | 66.23±11.35 | 67.47±10.27 | 62.93±9.99 | 0.079 |
BMI (kg/m) | 25.42±2.75 | 24.19±3.83 | 24.98±3.61 | 23.14±3.24 | 0.018 |
GERD-Q score | 9.5 (8, 12) | 8.5 (8, 11) | 10 (8, 11) | 8 (8, 10) | 0.165 |
Endoscopic finding | |||||
Erosive esophagitis | 77.78% | 50.00% | 55.56% | 49.45% | 0.171 |
Esophageal hiatal hernia | 38.89% | 16.67% | 50.00% | 20.88% | 0.025 |
HRM | |||||
CC (IEM/N) | 11/7 | 14/10 | 5/13 | 41/50 | |
SS DCI (mmHg·s·cm) | 389.50 (130.25, 774.75) | 405.00 (181.50, 893.75) | 504.00 (353.50, 1029.75) | 510.00 (274.00, 948.00) | 0.494 |
MRS DCI (mmHg·s·cm) | 405.00 (101.50, 855.00) | 472.50 (206.50, 876.00) | 495.50 (184.75, 925.75) | 422.00 (159.00, 849.00) | 0.986 |
MRS/SS DCI (mmHg·s·cm) | 0.98 (0.61, 1.52) | 0.97 (0.54, 1.70) | 0.93 (0.29, 1.32) | 0.87 (0.50, 1.23) | 0.615 |
CFV (cm/s) | 4.00 (3.28, 5.08) | 4.65 (3.98, 5.48) | 4.35 (3.63, 5.80) | 4.60 (3.70, 5.50) | 0.326 |
Break (cm) | 2.50 (0.65, 3.90) | 2.30 (1.30, 4.53) | 1.70 (1.00, 4.00) | 2.10 (1.10, 3.80) | 0.867 |
DL (s) | 6.65 (6.08, 7.53) | 7.25 (6.23, 7.85) | 6.80 (6.20, 7.30) | 6.80 (6.10, 7.40) | 0.720 |
IRP4 (mmHg) | 2.00 (−2.25, 2.00) | 1.00 (0, 4.00) | −0.50 (−2.00, 2.00) | 1.00 (−1.00, 4.00) | 0.103 |
MRS IRP4 (mmHg) | 0 (−1.25, 2.25) | 1.00 (−2.00, 4.25) | 0 (−1.00, 2.00) | 1.00 (−1.00, 4.00) | 0.557 |
LESP (mmHg) | 5.00 (3.75, 8.50) | 7.50 (2.00, 14.00) | 5.50 (2.75, 9.50) | 5.00 (1.00, 10.00) | 0.660 |
Length of LES (cm) | 2.82±0.51 | 2.97±0.47 | 2.93±0.52 | 2.91±0.42 | 0.749 |
Data are shown as the mean±SD, median (IQR) or number (%) of patients. BMI – body mass index; GERD – gastroesophageal reflux disease; CC – Chicago Classification; IEM – ineffective esophageal motility; N – normal; SS – single swallow; MRS – multiple rapid swallows; DL – distal latency; DCI – distal contractile integral; CFV – contractile front velocity; IRP – integrated relaxation pressure; LESP – lower esophageal sphincter pressure. |