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07 March 2021: Clinical Research

Association of Leptin Receptor Gene Polymorphisms with Keloids in the Chinese Han Population

Jing Liu 1ABCD , Limin Cai 1CDEF , Zepeng Zhang 1BCD , Yanli Ma 1BCDF , Yongchen Wang 2ADE*

DOI: 10.12659/MSM.928503

Med Sci Monit 2021; 27:e928503

Table 5 Associations between LEPR SNPs and family history of keloids.

SNPFamily-history kleoidnNo-family-history keloidnNormal controlsnP-valueaP-valuebOR (95%) CIbP-valuecOR (95%) CIc
 Codominant alleles AA/GG3/468/2272/2317.533 (1.224–46.349)4.070 (0.855–19.376)
 Dominant AA+GA/GG12/4667/22768/2310.9370.7320.886 (0.444–1.768)0.9891.003 (0.683–1.472)
 Recessive AA/GA+GG3/558/2862/2970.0390.0088.100 (1.323–49.603)0.0524.154 (0.875–19.727)
 Allele G/A101/15513/75528/700.8390.7090.893 (0.491–1.622)0.5810.907 (0.641–1.284)
 Codominant alleles CC/TT5/3819/17910/1912.513 (0.813–7.769)2.027 (0.918–4.478)
 Dominant CT+CC/TT20/38115/179108/1910.6740.8120.931 (0.516–1.680)0.4521.136 (0.815–1.584)
 Recessive CC/CT+TT5/5319/27510/2890.1110.0672.726 (0.896–8.296)0.0781.997 (0.912–4.370)
 Allele C/T25/91134/454118/4800.4360.6541.118 (0.687–1.817)0.1981.201 (0.909–1.587)
 Codominant alleles AA/GG2/408/2197/2311.650 (0.331–8.229)1.205 (0.430–3.380)
 Dominant GA+AA/GG18/4075/21968/2310.3740.1771.529 (0.824–2.838)0.4311.163 (0.798–1.696)
 Recessive AA/GA+GG2/568/2867/2920.8780.6231.490 (0.302–7.359)0.7681.167 (0.418–3.260)
 Allele G/A96/20505/83523/750.3680.1730.688 (0.401–1.180)0.4250.873 (0.624–1.220)
 Codominant alleles GG/AA3/3513/19310/2201.886 (0.494–7.192)1.482 (0.635–3.456)
 Dominant GA+GG/AA23/35101/19379/2200.0390.0411.830 (1.019–3.287)0.0361.457 (1.025–2.073)
 Recessive GG/GA+AA3/5513/28110/2890.7120.4961.576 (0.420–5.913)0.4971.337 (0.577–3.099)
 Allele G/A26/90114/47489/5090.0450.0431.652 (1.011–2.700)0.0391.375 (1.015–1.864)
LEPR – leptin receptor; SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval.
a Family-history keloid vs no-family-history keloid vs normal controls;
b Family-history keloid vs normal controls;
c No-family-history keloid vs normal controls.
Bold fonts indicate the P values of codominant alleles in different groups.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750