07 March 2021>: Clinical Research
Association of Leptin Receptor Gene Polymorphisms with Keloids in the Chinese Han Population
Jing Liu 1ABCD , Limin Cai 1CDEF , Zepeng Zhang 1BCD , Yanli Ma 1BCDF , Yongchen Wang 2ADE*DOI: 10.12659/MSM.928503
Med Sci Monit 2021; 27:e928503
Table 4 Associations between LEPR SNPs and keloid severity.
SNP | Mild-moderate kleoidn | Severe keloidn | Normal controlsn | P-valuea | P-valueb | OR (95% CI)b | P-valuec | OR (95% CI)c |
---|---|---|---|---|---|---|---|---|
rs1137101 | ||||||||
Dominant AA+GA/GG | 60/222 | 19/51 | 68/231 | 0.573 | 0.435 | 1.266 (0.700–2.288) | 0.292 | 0.725 (0.399–1.321) |
Recessive AA/GA+GG | 6/276 | 5/65 | 2/297 | 0.002 | 0.000 | 11.423 (2.168–60.176) | 0.031 | 0.283 (0.084–0.955) |
Allele G/A | 498/66 | 116/24 | 528/70 | 0.180 | 0.082 | 0.641 (0.387–1.062) | 0.084 | 1.561 (0.938–2.597) |
rs1938496 | ||||||||
Dominant CT+CC/TT | 106/176 | 29/41 | 108/191 | 0.705 | 0.408 | 1.251 (0.736–2.127) | 0.554 | 0.851 (0.500–1.451) |
Recessive CC/CT+TT | 16/266 | 8/62 | 10/289 | 0.021 | 0.005 | 3.729 (1.415–9.830) | 0.087 | 0.466 (0.191–1.138) |
Allele C/T | 122/442 | 37/107 | 118/480 | 0.200 | 0.08 | 1.461 (0.954–2.238) | 0.224 | 0.768 (0.502–1.176) |
rs6588147 | ||||||||
Dominant GA+AA/GG | 65/217 | 28/42 | 68/231 | 0.007 | 0.003 | 2.265 (1.307–3.923) | 0.004 | 0.449 (0.259–0.781) |
Recessive AA/GA+GG | 4/278 | 6/64 | 7/292 | 0.003 | 0.011 | 3.911 (1.272–12.028) | 0.001 | 0.153 (0.042–0.560) |
Allele G/A | 495/69 | 106/34 | 523/75 | 0.001 | 0.000 | 0.447 (0.283–0.705) | 0.000 | 2.301 (1.451–3.649) |
rs7555955 | ||||||||
Dominant GA+GG/AA | 90/192 | 34/36 | 79/220 | 0.001 | 0.000 | 2.630 (1.541–4.489) | 0.009 | 0.496 (0.292–0.844) |
Recessive GG/GA+AA | 8/274 | 8/62 | 10/289 | 0.003 | 0.005 | 3.729 (1.415–9.830) | 0.002 | 0.226 (0.082–0.626) |
Allele G/A | 98/466 | 42/98 | 89/509 | 0.000 | 0.000 | 2.451 (1.601–3.752) | 0.001 | 0.491 (0.322–0.748) |
LEPR – leptin receptor; SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval; n – number. a Randomized comparison of mild-moderate keloid, severe keloid and normal controls; b Severe keloid vs normal controls; c Mild-moderate keloid vs severe keloid. |