Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

07 March 2021: Clinical Research

Association of Leptin Receptor Gene Polymorphisms with Keloids in the Chinese Han Population

Jing Liu 1ABCD , Limin Cai 1CDEF , Zepeng Zhang 1BCD , Yanli Ma 1BCDF , Yongchen Wang 2ADE*

DOI: 10.12659/MSM.928503

Med Sci Monit 2021; 27:e928503

Table 4 Associations between LEPR SNPs and keloid severity.

SNPMild-moderate kleoidnSevere keloidnNormal controlsnP-valueaP-valuebOR (95% CI)bP-valuecOR (95% CI)c
 Dominant AA+GA/GG60/22219/5168/2310.5730.4351.266 (0.700–2.288)0.2920.725 (0.399–1.321)
 Recessive AA/GA+GG6/2765/652/2970.0020.00011.423 (2.168–60.176)0.0310.283 (0.084–0.955)
 Allele G/A498/66116/24528/700.1800.0820.641 (0.387–1.062)0.0841.561 (0.938–2.597)
 Dominant CT+CC/TT106/17629/41108/1910.7050.4081.251 (0.736–2.127)0.5540.851 (0.500–1.451)
 Recessive CC/CT+TT16/2668/6210/2890.0210.0053.729 (1.415–9.830)0.0870.466 (0.191–1.138)
 Allele C/T122/44237/107118/4800.2000.081.461 (0.954–2.238)0.2240.768 (0.502–1.176)
 Dominant GA+AA/GG65/21728/4268/2310.0070.0032.265 (1.307–3.923)0.0040.449 (0.259–0.781)
 Recessive AA/GA+GG4/2786/647/2920.0030.0113.911 (1.272–12.028)0.0010.153 (0.042–0.560)
 Allele G/A495/69106/34523/750.0010.0000.447 (0.283–0.705)0.0002.301 (1.451–3.649)
 Dominant GA+GG/AA90/19234/3679/2200.0010.0002.630 (1.541–4.489)0.0090.496 (0.292–0.844)
 Recessive GG/GA+AA8/2748/6210/2890.0030.0053.729 (1.415–9.830)0.0020.226 (0.082–0.626)
 Allele G/A98/46642/9889/5090.0000.0002.451 (1.601–3.752)0.0010.491 (0.322–0.748)
LEPR – leptin receptor; SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval; n – number.
a Randomized comparison of mild-moderate keloid, severe keloid and normal controls;
b Severe keloid vs normal controls;
c Mild-moderate keloid vs severe keloid.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750