07 March 2021: Clinical Research
Association of Leptin Receptor Gene Polymorphisms with Keloids in the Chinese Han Population
Jing Liu 1ABCD , Limin Cai 1CDEF , Zepeng Zhang 1BCD , Yanli Ma 1BCDF , Yongchen Wang 2ADE*DOI: 10.12659/MSM.928503
Med Sci Monit 2021; 27:e928503
Table 3 The frequencies of genotypes and alleles in LEPR gene.
| SNP | Keloid | Normal controls | P-value | OR (95% CI) | ||
|---|---|---|---|---|---|---|
| n | % | n | % | |||
| rs1137101 | ||||||
| GA | 68 | 19.32% | 66 | 22.07% | 0.386 | 0.845 (0.578–1.237) |
| GG | 273 | 77.56% | 231 | 77.26% | 0.927 | 1.017 (0.704–1.471) |
| AA | 11 | 3.13% | 2 | 0.67% | 0.026 | 4.790 (1.053–21.785) |
| G | 614 | 87.22% | 528 | 88.29% | 0.105 | 0.760 (0.546–1.059) |
| A | 90 | 12.78% | 70 | 11.71% | ||
| rs1938496 | ||||||
| CT | 111 | 31.53% | 98 | 32.78% | 0.735 | 0.945 (0.679–1.314) |
| CC | 24 | 6.82% | 10 | 3.34% | 0.047 | 2.115 (0.994–4.497) |
| TT | 217 | 61.65% | 191 | 63.88% | 0.557 | 0.909 (0.661–1.251) |
| C | 159 | 22.59% | 118 | 19.73% | 0.210 | 1.187 (0.908–1.551) |
| T | 545 | 77.41% | 480 | 80.27% | ||
| rs6588147 | ||||||
| GA | 83 | 23.58% | 61 | 20.40% | 0.330 | 1.204 (0.828–1.749) |
| GG | 259 | 73.58% | 231 | 77.26% | 0.278 | 0.82 (0.572–1.175) |
| AA | 10 | 2.84% | 7 | 2.34% | 0.690 | 1.220 (0.458–3.245) |
| G | 601 | 85.37% | 523 | 87.46% | 0.274 | 0.837 (0.608–1.152) |
| A | 103 | 14.63% | 75 | 12.54% | ||
| rs7555955 | ||||||
| GA | 108 | 30.68% | 69 | 23.08% | 0.030 | 1.475 (1.038–2.097) |
| GG | 16 | 4.55% | 10 | 3.34% | 0.435 | 1.376 (0.615–3.08) |
| AA | 228 | 64.77% | 220 | 73.58% | 0.016 | 0.660 (0.471–0.925) |
| G | 140 | 19.89% | 89 | 14.88% | 0.018 | 1.420 (1.061–1.900) |
| A | 564 | 80.11% | 509 | 85.12% | ||
| LEPR – leptin receptor; SNP – single nucleotide polymorphism; OR – odds ratio; CI – confidence interval; n – number. | ||||||