22 February 2021: Clinical Research
Fractional Exhaled Nitric Oxide (FeNO) Integrating Airway Hyperresponsiveness (AHR) Examination Promotes Etiologic Diagnosis and Treatment for Children with Chronic Cough
Haiyan Zhu 1BCDEF , Chuangli Hao 2BCDE , Xingmei Yu 2BCDF , Rongrong Zhang 1BCD , Wendi Zhou 1BCF , Xingzhen Sun 1BCF , Yufang Yuan 1BCF , Zhaofang Tian 1ABDEG*DOI: 10.12659/MSM.928502
Med Sci Monit 2021; 27:e928502
Table 3 Comparison of the levels of FeNO and other parameters before and after treatment for different etiologies of chronic cough (χ±s).
| Parameters | Before treatment | After treatment | P | ||||||
|---|---|---|---|---|---|---|---|---|---|
| CVA group (n=45) | UACS group (n=53) | PIC group (n=20) | CVA group (n=45) | UACS group (n=53) | PIC group (n=20) | CVA | UACS | PIC | |
| FeNO | 35±14 | 17±8 | 19±8 | 20±7 | 16±6 | 18±6 | 0.001 | 0.374 | 0.412 |
| EOS in sputum (%, median) | 6.5 (6) | 0.5 (1) | 0.5 (1.5) | 2 (3) | 0 (1) | 0 (1) | 0.002 | 0.510 | 0.356 |
| Cough symptom score | 3.5±0.7 | 3.2±0.7 | 3.2±1.0 | 1.5±0.8 | 1.8±0.8 | 1.0±0.9 | 0.000 | 0.000 | 0.000 |
| AHR cases (n) | 45 | 17 | 14 | 45 | 6 | 2 | – | – | – |
| PD20-FEV1 (mg) | 0.48±0.28 | 1.77±0.64 | 1.17±0.75 | 0.61±0.21 | 2.18±0.43 | 2.07±0.44 | 0.046 | 0.003 | 0.001 |
| CVA – cough-variant asthma; UACS – upper-airway cough syndrome; PIC – post-infection cough; FeNO – fractional exhaled nitric oxide; EOS – eosinophils; AHR – airway hyperresponsiveness; PD20-FEV – decrease of 20% in forced expiratory volume in 1 s. | |||||||||