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22 February 2021: Clinical Research

Fractional Exhaled Nitric Oxide (FeNO) Integrating Airway Hyperresponsiveness (AHR) Examination Promotes Etiologic Diagnosis and Treatment for Children with Chronic Cough

Haiyan Zhu 1BCDEF , Chuangli Hao 2BCDE , Xingmei Yu 2BCDF , Rongrong Zhang 1BCD , Wendi Zhou 1BCF , Xingzhen Sun 1BCF , Yufang Yuan 1BCF , Zhaofang Tian 1ABDEG*

DOI: 10.12659/MSM.928502

Med Sci Monit 2021; 27:e928502

Table 3 Comparison of the levels of FeNO and other parameters before and after treatment for different etiologies of chronic cough (χ±s).

ParametersBefore treatmentAfter treatmentP
CVA group (n=45)UACS group (n=53)PIC group (n=20)CVA group (n=45)UACS group (n=53)PIC group (n=20)CVAUACSPIC
EOS in sputum (%, median)6.5 (6)0.5 (1)0.5 (1.5)2 (3)0 (1)0 (1)0.0020.5100.356
Cough symptom score3.5±0.73.2±0.73.2±1.01.5±0.81.8±0.81.0±0.90.0000.0000.000
AHR cases (n)4517144562
PD20-FEV1 (mg)0.48±0.281.77±0.641.17±0.750.61±0.212.18±0.432.07±0.440.0460.0030.001
CVA – cough-variant asthma; UACS – upper-airway cough syndrome; PIC – post-infection cough; FeNO – fractional exhaled nitric oxide; EOS – eosinophils; AHR – airway hyperresponsiveness; PD20-FEV – decrease of 20% in forced expiratory volume in 1 s.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750