25 February 2021: Clinical Research
Preoperative Computed Tomography Imaging of the Pancreas Identifying Predictive Factors for the Progression of Grade A, or Biochemical Leak, to Grade B Postoperative Pancreatic Fistula Following Pancreaticoduodenectomy: A Retrospective Study
Feng-Hao Liu 12ABCDEF , Xiao-Zhong Jiang 12ABCE* , Bin Huang 1AEF , Yu Yu 1DFDOI: 10.12659/MSM.928489
Med Sci Monit 2021; 27:e928489
Table 1 Univariate analysis of risk factors for progression from biochemical leak to grade B pancreatic fistula.
| Variable | Postoperative pancreatic fistula (POPF) progression | |||
|---|---|---|---|---|
| Yes | No | χ2 | P value | |
| Sex | ||||
| Male | 15 (62.5%) | 16 (44.4%) | 1.880 | 0.170 |
| Female | 9 (37.5%) | 20 (55.6%) | ||
| Age (yr)* | 62.5±5.0 | 62.3±5.8 | 0.345 | 0.856 |
| BMI (kg/m)** | 24.60 (2.65) | 24.60 (3.00) | 0.955 | 0.683 |
| PT (s)** | 12.60 (1.4) | 12.60 (1.2) | 0.598 | 0.833 |
| Serum albumin (g/L)** | 35.40 (2.6) | 35.90 (2.4) | 0.996 | 0.752 |
| Preoperative total bilirubin (μmol/L)* | ||||
| ≥171 | 11 (45.8%) | 13 (36.1%) | 0.567 | 0.451 |
| 13 (54.2%) | 23 (63.9%) | |||
| Preoperative ALT (U/L)* | 76.5±14.0 | 72.7±13.3 | 0.582 | 0.295 |
| Preoperative CT value (HU)* | 40.1±2.7 | 43.9±3.4 | 0.426 | 0.0001 |
| MPD (mm) | ||||
| ≥3 | 8 (33.3%) | 24 (66.7%) | 6.429 | 0.011 |
| 16 (66.7%) | 12 (33.3%) | |||
| Operative time (min)* | 366.3±20.9 | 358.0±23.9 | 0.370 | 0.177 |
| Blood loss (ml) | ||||
| ≥600 | 12 (50.0%) | 22 (61.1%) | 0.724 | 0.395 |
| 12 (50.0%) | 14 (38.9%) | |||
| Postoperative PT (s)* | 16.4±1.3 | 14.8±1.2 | 0.879 | 0.0001 |
| Postoperative serum albumin (g/L)* | 29.6±2.4 | 33.2±2.5 | 0.723 | 0.0001 |
| Postoperative total bilirubin (μmol/L)* | ||||
| ≥171 | 9 (37.5%) | 10 (27.8%) | 0.629 | 0.428 |
| 15 (62.5%) | 26 (72.2%) | |||
| Postoperative ALT (U/L)* | 54.4±9.9 | 52.2±5.9 | 0.166 | 0.302 |
| Postoperative complication | ||||
| Yes | 5 (20.8%) | 1 (3.0%) | 5.216 | 0.022 |
| No | 19 (79.2%) | 35 (97.0%) | ||
| Pathological type of tumour | ||||
| Benign tumour | 0 (0.0%) | 1 (2.8%) | 0.753 | 0.686 |
| Low grade malignant tumour | 1 (4.2%) | 1 (2.8%) | ||
| High grade malignant tumour | 23 (95.8%) | 34 (94.4%) | ||
| yr – years old; postoperative – on postoperative 3 days; BMI – body mass index; PT – prothrombin time; ALT – alanine aminotransferase; MPD – main pancreatic duct. HU – Hounsfield Unit. * Values are mean±standard deviation; ** median (interquartile range). | ||||