15 February 2021: Clinical Research
Polymorphisms in and Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population
Yuqin Peng BC , Bingqian Chen BCD , Xiaowen Sheng DE , Yufeng Qian AEG*DOI: 10.12659/MSM.928455
Med Sci Monit 2021; 27:e928455
Table 4 Haplotypes structure and frequencies of IRF5 and TYK2 gene polymorphism.
| Genes | Number | Haplotypes | Case | Control | P | OR [95%CI] |
|---|---|---|---|---|---|---|
| I | DTAT | 167 (0.144) | 115 (0.099) | 0.0009 | 1.54 [1.191~1.976] | |
| I | DTAG | 317 (0.274) | 370 (0.320) | 0.02 | 0.81 [0.673~0.962] | |
| I | DTGT | 18 (0.016) | 22 (0.019) | 0.61 | 0.85 [0.455~1.591] | |
| I | DTGG | 48 (0.041) | 95 (0.082) | 4.45e-005 | 0.48 [0.337~0.688] | |
| I | ITAT | 61 (0.052) | 37 (0.032) | 0.01 | 1.69 [1.114~2.572] | |
| I | ITAG | 259 (0.224) | 261 (0.226) | 0.95 | 0.99 [0.817~1.208] | |
| I | ITGT | 44 (0.038) | 46 (0.039) | 0.87 | 0.97 [0.632~1.472] | |
| I | ITGG | 236 (0.204) | 207 (0.179) | 0.12 | 1.18 [0.957~1.449] | |
| T | AAAGT | 43 (0.037) | 14 (0.012) | 9.88e-005 | 3.18 [1.723~5.878] | |
| T | AAGAT | 35 (0.030) | 24 (0.021) | 0.15 | 1.46 [0.866~2.472] | |
| T | AAGGG | 12 (0.011) | 10 (0.009) | 0.66 | 1.20 [0.524~2.753] | |
| T | AAGGT | 83 (0.072) | 80 (0.069) | 0.79 | 1.04 [0.758~1.434] | |
| T | AGAGT | 26 (0.022) | 13 (0.011) | 0.05 | 1.96 [1.005~3.838] | |
| T | AGGAT | 67 (0.058) | 29 (0.025) | 9.82e-005 | 2.35 [1.513~3.667] | |
| T | AGGGT | 73 (0.063) | 80 (0.069) | 0.55 | 0.90 [0.651~1.255] | |
| T | GAAAT | 42 (0.036) | 17 (0.015) | 0.001 | 2.52 [1.427~4.460] | |
| T | GAAGT | 58 (0.050) | 48 (0.042) | 0.34 | 1.21 [0.819~1.789] | |
| T | GAGAT | 71 (0.061) | 87 (0.075) | 0.18 | 0.80 [0.578~1.108] | |
| T | GAGGT | 220 (0.190) | 304 (0.263) | 2.60e-005 | 0.65 [0.538~0.799] | |
| T | GGAAT | 12 (0.011) | 9 (0.008) | 0.55 | 1.29 [0.552~3.032] | |
| T | GGAGT | 56 (0.049) | 54 (0.046) | 0.82 | 1.04 [0.713~1.535] | |
| T | GGGAT | 58 (0.050) | 59 (0.051) | 0.87 | 0.97 [0.668~1.408] | |
| T | GGGGG | 23 (0.020) | 33 (0.029) | 0.41 | 0.92 [0.745~1.126] | |
| D – deletion; I – insertion; OR – odds ratio; 95% CI – 95% confidence intervals, ‘−‘ – not calculated. a The program, Plink, was used to estimate common (frequency[0.01) haplotypes constructed by the SNPs of IRF5 (exon 6 (in/de), rs2070197, rs10954213, rs2004640) and five SNPs of TYK2 genotyped (rs280500, rs280519, rs280521, rs8108236, rs12720253). b Each haplotype was compared with the other haplotypes combined. c The Bonfferoni correction was applied to correct the p value. | ||||||